1/23. Desmoplastic spindle-cell melanoma of the eyelid with orbital invasion.PURPOSE: To describe the clinicopathologic features of a patient with a spindle-cell melanoma of the eyelid that exhibited orbital invasion. methods: Case report. RESULTS: A slowly enlarging mass developed in the eyelid of a 50-year-old woman. Excision of the mass showed desmoplastic spindle-cell melanoma. The tumor recurred in the orbit, and an exenteration was performed. A second recurrence 7 months later was treated with radiation therapy. CONCLUSIONS: There is a continuum of spindle-cell to desmoplastic melanoma. The prognosis of patients with orbital invasion of melanoma is poor, and adjuvant treatment including radiation and chemotherapy has little benefit.- - - - - - - - - - ranking = 1keywords = spindle (Clic here for more details about this article) |
2/23. Giant cell angiofibroma of the orbit and eyelid.PURPOSE: To report the clinicopathologic features of a newly recognized tumor, giant cell angiofibroma. DESIGN: Observational case series. MAIN OUTCOME MEASURES: Clinical and histopathologic features of giant cell angiofibroma. methods: light and electron microscopy and immunohistochemistry of five cases of giant cell angiofibroma. RESULTS: A total of five patients (4 women and 1 man) are described: two presented with a painless mass in the eyelid, two with a mass in the orbit, and one presented with a conjunctival lesion. All lesions were well demarcated with no capsule and were composed of blood vessels, a patternless spindle-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin. CONCLUSION: Giant cell angiofibroma resembles solitary fibrous tumor and giant cell fibroblastoma and should be considered in the differential diagnosis of spindle-cell tumors in the eyelid, orbit, and conjunctiva.- - - - - - - - - - ranking = 0.42857142857143keywords = spindle (Clic here for more details about this article) |
3/23. neurothekeoma palpebrae: a rare nerve sheath tumor arising in the eyelid.PURPOSE: To report a case of an eyelid neurothekeoma, a rare peripheral nerve sheath tumor. methods: Case report. RESULTS: An excisional biopsy, performed on a lesion removed from the upper eyelid of a 76-year-old woman, revealed the clinical and histopathologic features of a neurothekeoma, a tumor consisting of multiple collections of spindle cells in a myxomatous background. Immunohistochemical characterization showed positivity for NK1/C3, neuron-specific enolase, and alcian blue. CONCLUSION: neurothekeoma palpebrae should be considered in the differential diagnosis of solitary nodules of the eyelids.- - - - - - - - - - ranking = 0.32469118506776keywords = spindle cell, spindle (Clic here for more details about this article) |
4/23. The panda naevus: management of synchronous upper- and lower-eyelid pigmented naevi.We report four patients presenting with rare synchronous upper- and lower-eyelid naevi. The distributions and appearances of these naevi resemble the distinctive periorbital pigmentation of the panda. The possible embryological origin of this naevus and an approach to management are discussed.- - - - - - - - - - ranking = 56.12734466195keywords = naevus (Clic here for more details about this article) |
5/23. Immunohistochemical diagnosis of a rare case of epithelioid malignant peripheral nerve sheath tumor with multiple metastases.BACKGROUND: The epithelioid variant of malignant peripheral nerve sheath tumor (MPNST) is a rare tumor with poor prognosis that sometimes involves the head and neck. The diagnosis is based principally on the histological examination, and it is generally very difficult to reach the correct diagnosis. CASE: An 84-year-old Japanese woman presented with a tumor mass of 2 week's duration in the right medial canthal region. OBSERVATIONS: Although the tumor was excised surgically, metastases occurred three times on her face and head, and the patient died of distant systemic multiple metastases. In the histopathological analysis, the tumor showed a composite pattern comprising spindle or polygonal cells arranged in irregular bands, and a population of larger epithelioid cells in solid sheets and nests. In the immunohistochemical analysis, the tumor cells were positive for S-100 protein, vimentin, and nerve growth factor receptor (NGFR), and negative for cytokeratin and HMB 45 (melanoma-associated antigen). These findings confirmed the diagnosis of MPNST. CONCLUSIONS: Epithelioid MPNST has complex histopathological findings and histopathological features similar to other epithelioid tumors, especially malignant melanoma. Immunohistochemical examination using NGFR and HMB-45 is important in the differential diagnosis.- - - - - - - - - - ranking = 0.14285714285714keywords = spindle (Clic here for more details about this article) |
6/23. Solitary superficial angiomyxoma in the eyelid.PURPOSE: To report the clinicopathologic features of a solitary superficial angiomyxoma arising in the eyelid. DESIGN: Case report. methods: A retrospective review of the clinical and pathologic features of a patient with solitary superficial angiomyxoma in the eyelid. RESULTS: A 47-year-old male presented with a right upper lid mass for 6 months. Excisional biopsy was performed, and microscopic examination revealed a tumor comprising loose spindle or stellate-shaped cells in myxoid stroma sprinkled with small numbers of neutrophils. The tumor cells were negative for smooth muscle actin, desmin, S-100 protein, and CD34 on immunostaining. CONCLUSIONS: Ophthalmologists should be aware of superficial angiomyxoma as a rare cutaneous tumor with a tendency for local recurrence. Multiple lesions and occurrence in the external ear can be associated with the Carney's complex.- - - - - - - - - - ranking = 0.14285714285714keywords = spindle (Clic here for more details about this article) |
7/23. Hemi-naevus of Ota: perturbation of neural crest differentiation as a likely mechanism.We present a case of oculodermal melanosis that involves the lower eyelid and lower half of the globe in a very clearly defined fashion. We suggest that such a lesion is the result of a local change in embryonic environment occurring during a well-defined stage of ocular development, such that differentiation of neural crest cells into a melanocytic phenotype is favoured.- - - - - - - - - - ranking = 44.90187572956keywords = naevus (Clic here for more details about this article) |
8/23. Solitary eyelid Kaposi sarcoma in an hiv-negative patient.PURPOSE: To describe a case of localized Kaposi sarcoma (KS) of the eyelid in an hiv-seronegative patient. methods: An 80-year-old man developed an ulcerated nodular tumor-like mass that grew rapidly on his left upper eyelid. There were no similar lesions elsewhere. The eyelid lesion was completely excised and histopathologically examined. Serological analyses and molecular biologic techniques, including polymerase chain reaction, were used. RESULTS: Laboratory examinations were within normal limits, and serology for hiv was negative. Histological sections revealed a vascular proliferation composed predominantly of small slit-like blood vessels and epithelioid spindle cells, supporting the diagnosis of KS. polymerase chain reaction was positive for human herpesvirus 8. During a 2-year follow-up, no recurrences, development of new lesions, or hiv seroconversions were observed. CONCLUSION: This is a classic KS involving only the eyelid in an hiv-negative patient. Location in the eyelid is a possible, albeit rare, initial solitary manifestation of KS in elderly hiv-negative patients. Surgery is both safe and effective.- - - - - - - - - - ranking = 0.32469118506776keywords = spindle cell, spindle (Clic here for more details about this article) |
9/23. Haemangioendothelioma on the conjunctiva of the upper eyelid.A 62-year-old man visited the authors' clinic complaining of a mass on the palpebral conjunctiva of the right upper eyelid. The 2.0 cm x 1.2 cm sized, red and painless mass underwent incision and biopsy for histopathological examination. The mass was confirmed to be Kaposiform haemangioendothelioma characterized by densely packed spindle cells. These cells were positive to vimentin, CD31 and factor viii-related antigen by immunohistochemical stain. The mass was completely resolved by oral steroid therapy and has not recurred through the presentation. Kaposiform haemangioendothelioma generally occurs in infant and adolescent periods and is characterized by rapid progression and invasion to adjacent tissue. Herein, an unusual case of Kaposiform haemangioendothelioma affecting the conjunctiva of the upper eyelid on a middle-aged man is reported.- - - - - - - - - - ranking = 0.32469118506776keywords = spindle cell, spindle (Clic here for more details about this article) |
10/23. Periocular malignant fibrous histiocytoma.We present a case of periocular cutaneous malignant fibrohistiocytoma that invaded the orbit. Complete excision is recommended for atypical fibrohistiocytic tumors around the eye. Examination of specimen margins by frozen section should be undertaken with caution. It is recommended that frozen section evaluation be performed by a pathologist familiar with spindle cell neoplasm to ensure complete removal of this tumor.- - - - - - - - - - ranking = 0.32469118506776keywords = spindle cell, spindle (Clic here for more details about this article) |
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