1/28. Malignant melanoma of the choroid in neurofibromatosis.A 60-year-old white woman with generalized neurofibromatosis and multiple melanocytic hamartomas of the iris developed an unusual choroidal mass, with secondary sensory retinal separation in the left eye. Ophthalmoscopically the tumor had a peculiar donut configuration that was caused by a large focus of central necrosis within a spindle B melanoma.- - - - - - - - - - ranking = 1keywords = spindle (Clic here for more details about this article) |
2/28. Solitary fibrous tumor of the lacrimal sac.PURPOSE: Solitary fibrous tumor is a rare spindle cell tumor arising in the pleura. We report two cases of this tumor occurring in the lacrimal sac. methods: A 23-year-old man and a 34-year-old woman presented with a medial canthal mass. They underwent surgical excision of their tumors. RESULTS: solitary fibrous tumors were diagnosed by light microscopy, immunohistochemical study, and electron microscopy. Immunohistochemical staining showed that tumor cells were reactive with vimentin and CD34 and demonstrated no smooth muscle or neural differentiation (nonreactive with desmin and S-100 protein). CONCLUSIONS: The findings indicate that solitary fibrous tumor can occur in the lacrimal sac and may recur locally if it is removed incompletely. To our knowledge, these are the first reported cases of solitary fibrous tumors occurring in the lacrimal sac.- - - - - - - - - - ranking = 2.2322926322575keywords = spindle cell, spindle (Clic here for more details about this article) |
3/28. Clinicopathological report Periocular tumour of the follicular infundibulum.Tumour of the follicular infundibulum (TFI) is an uncommon, benign lesion of the skin adnexae. Four cases are reported of periocular TFI. In all cases a clinical diagnosis of basal cell carcinoma was made before surgery; however, histopatholog ca examination revealed TFI. This is an epithelial tumour showing differentiation along the lines of the follicular infundibulum. Characteristic features are a shelf-like proliferat on of pale epithelia cells in the upper dermis, attachment to the epidermis and the upper portions of the pilosebaceous units, a dense border of elastic fibres, and palisading of the peripheral cell layer of the tumour plate. This benign tumour has not, to the authors' knowledge, been reported in the ophthalmic literature. It has a non-specific appearance and may be clinically misdiagnosed as naevus sebaceous, xanthoma, seborrhoeic keratosis, or basal cell carcinoma.- - - - - - - - - - ranking = 70.229217219269keywords = naevus (Clic here for more details about this article) |
4/28. Giant cell angiofibroma of the nasolacrimal duct.PURPOSE: To describe clinical and histologic features of the first case, to our knowledge, of giant cell angiofibroma located in the nasolacrimal duct region in a 28-year-old woman. methods: Interventional case report. A left nasolacrimal duct tumor was excised en bloc by lateral rhinotomy. Histopathologic examination was performed with the use of light microscopy. Immunohistochemical staining included S-100 protein, muscle-specific actin, desmin, myoglobin, vimentin, and CD34. RESULTS: The lesion was characterized by haphazardly arranged oval to spindled cells, a myxoid and collagenous stroma, multinucleated giant cells, prominent blood vessels, and pseudovascular spaces. Tumor cells were strongly positive for vimentin and CD34 and were negative for other antigens. After excision, there has been no recurrence over 4 years of follow-up. CONCLUSIONS: Originally described as an orbital tumor, giant cell angiofibroma also may occur in the nasolacrimal duct and lacrimal sac region. This mesenchymal neoplasm should be included in the differential diagnosis of lacrimal drainage system tumors.- - - - - - - - - - ranking = 1keywords = spindle (Clic here for more details about this article) |
5/28. Corneal myxoma.BACKGROUND: Myxomas are rare benign tumors that can be found most frequently in the heart. We report the clinical and histological findings in a very rare case of corneal myxoma, which is only the sixth case in the literature. CASE: A whitish elevated tumor of the anterior cornea developed in the left eye cornea of a 46-year-old man 2 years after luxation of the patient's lens into the anterior chamber and subsequent endothelial decompensation. The tumor covered the entire surface of the cornea except for the outer limbal periphery at Schwalbe's line. OBSERVATIONS: Histologically, the hypocellular tumor was characterized by scattered spindle- and stellate-shaped cells with wavy, randomly oriented collagen fibers in a myxomatous ground substance staining positively for acid mucopolysaccharides. Bowman's layer was absent. Immunohistochemically, the tumor cells were positive for vimentin. Ultrastructurally, the tumor cells had features characteristic of keratocytes with no basement membrane, much rough endoplasmic reticulum and vacuoles containing mucoid-like material. CONCLUSIONS: The ultrastructural observations support the hypothesis of a cellular origin of the myxoma from keratocytes. The tumor growth was most probably stimulated by chronic endothelial failure and bullous keratopathy.- - - - - - - - - - ranking = 1keywords = spindle (Clic here for more details about this article) |
6/28. A corneal diffuse neurofibroma as a manifestation of von recklinghausen disease.PURPOSE: To report a case of a primary corneal diffuse neurofibroma in a patient with von Recklinghausen disease (NF-1). methods: Case report. A physical examination and histopathology were performed. The immunohistochemical studies were performed using an avidin-biotin-peroxidase complex technique on formalin-fixed and paraffin-embedded tissue. Histologic sections from corneal tissue were incubated with primary antibodies against vimentin and S-100 protein. A complementary ultrastructural study of the same formalin-fixed and paraffin-embedded tissue was made. RESULTS: The ophthalmologic examination revealed a yellowish-white elevated mass that involved the supratemporal cornea but not the limbus. Histologic study showed a tumor of the peripheral nerve sheath, a diffuse neurofibroma in the corneal stroma, and proliferation of spindle cells with markedly elongated nuclei. Cells comprising the tumor reacted with vimentin and S-100 protein, and the ultrastructural studies revealed myelinated nerve fibers confirming the diagnosis. CONCLUSION: The development of a primary diffuse neurofibroma in the cornea of patients with von Recklinghausen disease is possible. The present case supports the statement that neurofibromas arising from the peripheral nerve sheath may involve any part of the body.- - - - - - - - - - ranking = 2.2322926322575keywords = spindle cell, spindle (Clic here for more details about this article) |
7/28. Encephalocraniocutaneous lipomatosis: a case with unilateral odontomas and review of the literature.We report a 7-year-old boy with the typical features of encephalocraniocutaneous lipomatosis (ECCL) including unilateral skin, eye, bone, and asymptomatic central nervous system involvement. The presenting sign were numerous ipsilateral odontomas which have been described in only two previous patients so far. We reviewed all 32 cases reported to date and focus on the dermatological hallmark of the condition, namely a fatty tissue naevus of the scalp for which the term naevus psiloliparus was recently coined. Sporadic occurrence, patchy type of organ involvement and roughly balanced sex ratio in ECCL are compatible with the concept of a lethal autosomal mutation only surviving in a mosaic state. CONCLUSION: In children presenting with a congenital smooth hairless lesion on the scalp, the diagnosis of naevus psiloliparus should be considered and other signs of encephalocraniocutaneous lipomatosis should be looked for.- - - - - - - - - - ranking = 210.68765165781keywords = naevus (Clic here for more details about this article) |
8/28. myoepithelioma of the lacrimal gland: report of a case with spindle cell morphology.The case is described of a 23-year-old female patient presenting with unilateral proptosis, headaches, and transient epiphora. Surgery revealed an encapsulated tumour composed exclusively of spindle-shaped cells within a richly vascularised myxoid stroma. Immunohistochemical staining showed focal positivity for smooth muscle actin, vimentin, and glial fibrillary acidic protein. These combined findings are interpreted as providing evidence of a myoepithelioma, which may be regarded as a monomorphic adenoma consisting solely of myoepithelial cells. To our knowledge this is only the second report of such a tumour in the lacrimal gland.- - - - - - - - - - ranking = 9.9291705290301keywords = spindle cell, spindle (Clic here for more details about this article) |
9/28. Intraocular inflammatory myofibroblastic tumor with ALK overexpression.We report a case of an intraocular inflammatory myofibroblastic tumor nearly filling the vitreous cavity of the eye of a 50-year-old man. The tumor was composed of a mixture of spindle cells and mixed inflammatory elements, including numerous plasma cells. The differential diagnosis included inflammatory pseudotumor and neoplastic mimics of this condition. Further investigation with immunohistochemistry revealed the mass to be composed of myofibroblasts, positive for smooth muscle actin stains and with weak anaplastic lymphoma kinase (ALK) expression in some tumor cells. Evaluation by fluorescence in situ hybridization revealed the tumor cells to have multiple copies of chromosome 2 and ALK but no rearrangement of the ALK gene. The authors propose that multiple copies of the ALK gene may be involved in inflammatory myofibroblastic tumor tumorigenesis, in addition to ALK gene rearrangements.- - - - - - - - - - ranking = 2.2322926322575keywords = spindle cell, spindle (Clic here for more details about this article) |
10/28. Primary corneal myxoma.PURPOSE: To present the clinical and histopathological characteristics of a corneal myxoma. methods: A 36-year-old, white woman presented with blurred vision and a whitish opacity on the left cornea. Clinical examination revealed a whitish, non-tender, 5 x 9 mm superficial tumour on the cornea. The tumour was excised and examined microscopically. RESULTS: The tumour was composed of spindle-shaped cells in a myxomatous ground substance. Immunohistochemically, the tumour cells were positive for vimentin, muscle-specific antigen and smooth muscle antigen. The tumour was classified as a myxoma of the cornea. The origin of the tumour is discussed. CONCLUSION: This is the second reported case of a corneal myxoma without prior corneal disease.- - - - - - - - - - ranking = 1keywords = spindle (Clic here for more details about this article) |
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