21/55. Giant gangliocytic paraganglioma of the filum terminale. Case report.The clinical and pathological features of a giant cauda equina paraganglioma arising from the intradural filum terminale is described. Scattered mature large neurons characterized the tumor as a gangliocytic paraganglioma. Histologically, these neoplasms have considerable similarity with ependymoma and the diagnosis can be easily missed unless special techniques are employed.- - - - - - - - - - ranking = 1keywords = glioma (Clic here for more details about this article) |
22/55. Clear cell ependymoma. A histological variant with diagnostic implications.Four cystic brain tumours, one from the frontal lobe, one in the third ventricle and two in the cerebellum, were studied histologically including immunostaining and electron microscopy. Anatomically, all the tumours were located within or adjacent to the ventricular system. By light microscopy, the tumours had a largely honeycomb pattern and were made up of clear cells. Some of the clear cells showed positive for GFAP. Leu 7, factor viii and NSE were negative. Electron microscopy of the areas with clear cells revealed densely packed polyhedral cells with clear cytoplasm. They had well developed intercellular junctions, microvilli and some cilia which confirmed their ependymal derivation. Perivascular pseudorosettes or papillary features were only seen in limited areas, where GFAP was strongly positive in the tumour cell processes. As these tumours mimic oligodendroglioma and cerebellar haemangioblastoma, they are called as "clear cell ependymoma" to obviate such errors in diagnosis.- - - - - - - - - - ranking = 0.16666666666667keywords = glioma (Clic here for more details about this article) |
23/55. Metastatic carcinoma to glioma: a report of three cases with a critical review of the literature.Three cases are reported of primary bronchial carcinoma with metastatic deposits in an intracranial glioma (two cerebral astrocytomas and one fourth ventricle ependymoma). The rarity of this phenomenon is emphasised and the literature critically reviewed.- - - - - - - - - - ranking = 0.83333333333333keywords = glioma (Clic here for more details about this article) |
24/55. Intracerebral subependymomas. Clinical and neuropathological analyses with special reference to the possible existence of a less benign variant.The frequency of asymptomatic subependymomas was 0.4% in 1,000 serial routine necropsies and 0.7% in symptomatic subependymomas from 1,000 serial surgical specimens of intracranial neoplasms. Among patients with subependymoma (7 symptomatic and 4 asymptomatic), we found 3 cases of marked nuclear polymorphism (NP) in biopsy specimens. The subjective NP was objectively quantified by computer-assisted morphometry, by which a significant difference in nuclear size between these three cases and other cases (p less than 0.005) was revealed. This morphological characteristic correlated with the results of dna-analysis by flow fluorescence cytometry (FFCM): subependymomas with NP demonstrated higher S and G2/M phases in a diploid pattern than other benign gliomas of our series. From the clinical data including prognosis, however, no remarkable difference was found between the NP group and other groups. The possible existence of less benign variant should be considered in the diagnosis and treatment of subependymoma.- - - - - - - - - - ranking = 0.16666666666667keywords = glioma (Clic here for more details about this article) |
25/55. Compressive optic neuropathy and ependymoma of the third ventricle.Progressive monocular visual loss was the presenting manifestation of a cystic ependymoma arising from the third ventricle. Extracerebral extension of the tumor into the prechiasmatic cistern compressed the right optic nerve. Subfrontal extension caused erosion of the planum sphenoidale. Subtotal excision of the tumor was followed by cranial irradiation, and no further visual loss occurred. Extracerebral growth of primary intracerebral gliomas may cause optic neuropathy that is indistinguishable from other compressive neuropathies.- - - - - - - - - - ranking = 0.16666666666667keywords = glioma (Clic here for more details about this article) |
26/55. Mixed ependymoma-astrocytoma (subependymoma?) of the cerebral cortex.Tumors of mixed glial origin may present as low-grade neoplasms with distinct cell populations or as polymorphic malignant gliomas. Such cell populations are usually appropriate to the location of the tumor. A mixed tumor, with a cell population inappropriate to tumor location, is presented to discuss theories of glial differentiation and cellular heterogeneity. This mixed ependymoma-astrocytoma of the parietal cortex, ultrastructurally similar to subependymoma but anatomically separate from the subependymal cell matrix or ventricular surface, gives evidence for neoplastic differentiation into ependymal and astrocytic cell lines. This supports the idea of a common progenitor cell, the ependymoglia or tanycyte, in human cerebral cortex.- - - - - - - - - - ranking = 0.16666666666667keywords = glioma (Clic here for more details about this article) |
27/55. Primary leptomeningeal ependymoblastoma. Case report.Ependymoblastoma is considered to be a primitive malignant glioma with ependymal differentiation. This rare tumor occurs in very early life and shows rapid growth and a diffuse infiltration through the leptomeningeal space. The tumor cells are highly immature, with numerous mitoses and multilayered ependymal rosettes. The ependymoblastoma described in this report was found in a 17-year-old girl. In spite of detailed clinical and postmortem examinations, no definite primary site was identified in the neuraxis. The lesion spread predominantly throughout the leptomeningeal space. Histological analysis strongly suggested that this tumor originated from a heterotopic glial nest in the subarachnoid space. The absence of immunohistochemical neural tissue markers, glial fibrillary acidic protein, S-100 protein, neuron-specific enolase, and neurofilaments ruled out neuronal or glial differentiation. The authors were unable to find any previous report of primary leptomeningeal ependymoblastoma.- - - - - - - - - - ranking = 0.16666666666667keywords = glioma (Clic here for more details about this article) |
28/55. Metastasizing myxopapillary ependymoma of the sacrococcygeal region. A clinico-pathologic, light- and electronmicroscopic, immunohistochemical, tissue culture, and cytogenetic analysis of a case.A case of recurrent and metastasizing subcutaneous myxopapillary ependymoma of the sacrococcygeal region in a 44-year-old man is reported. The tumor was characterized light microscopically by numerous papillary projections, lined by epithelium-like cells, with a variable degree of polymorphism. Histochemical analysis relating to glucosaminoglycans indicated the presence of hyaluronic acid and chondroitin-4- and/or 6-sulfate. Using immunoperoxidase techniques, glial fibrillary acidic protein (GFAP) and S-100 protein were demonstrated within the tumor cells. Ultrastructurally, the tumor cells were characterized by an abundance of intermediate cytoplasmic filaments, prominent interdigitating cytoplasmic projections, the formation of desmosomes and external lamina-like material. The growth pattern in the tissue culture of this tumor is described, and the ultrastructural appearance of the cultured cells revealed features similar to the primary and recurrent tumor. Chromosome analyses by the G-banding technique of early generations of cultured tumor cells revealed a normal diploid stemline without gross chromosomal deviations. Among the different variant cells and clones recorded, those with x chromosome deviations were of special interest since gonosomal deviations have previously been observed in other types of glioma. The differential diagnosis against adenopapillary carcinoma, chordoma and malignant teratoma is briefly discussed.- - - - - - - - - - ranking = 0.16666666666667keywords = glioma (Clic here for more details about this article) |
29/55. The cytopathology of reactions to ventricular shunts.A common cause of malfunctioning ventricular shunts is the occlusion of either tip by a variety of normal or reactive tissues and foreign substances. A six-year-old girl with communicating hydrocephalus and a meningomyelocele, a 48-year-old man with an ependymoma and an 11-year-old boy with a pineal germinoma had multinucleated histiocytic giant cells and ependymal cells in cerebrospinal fluid obtained from their ventricular shunts. These cellular changes were interpreted as the cytologic counterpart of the foreign-body inflammatory reactions often seen histologically on occluded shunt tips. Numerous clusters of benign choroid plexus epithelium were found in an ascitic fluid from a six-year-old girl with an optic nerve glioma and a ventriculoperitoneal shunt. Such embolism of normal tissues must be distinguished from metastases from intracranial neoplasms.- - - - - - - - - - ranking = 0.16666666666667keywords = glioma (Clic here for more details about this article) |
30/55. Chemodectoma of the cauda equina: case report.Well-differentiated paragangliomas have been found in unusual sites where conspicuous paraganglions are not normally found. A patient with a chemodectoma of the cauda equina is described. The importance of differentiating such tumors from those far more commonly seen in the region of the cauda equina, namely, ependymomas, hemangioblastomas, and metastatic carcinomas is emphasised.- - - - - - - - - - ranking = 0.16666666666667keywords = glioma (Clic here for more details about this article) |
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