1/18. The use of microsatellite instability in the distinction between synchronous endometrial and colonic adenocarcinomas.The association of endometrial carcinoma with other gynecologic neoplasms, especially ovarian and fallopian tube carcinoma, has been well documented and is usually interpreted as a result of a field defect. Sporadic synchronous primary carcinomas occurring in the endometrium and colon are extremely rare, especially in the absence of the familial genetic abnormalities seen in hereditary nonpolyposis colorectal carcinoma (HNPCC) syndrome, and may present a diagnostic dilemma. Two cases of synchronous adenocarcinomas of the endometrium and colon were studied for genetic abnormalities and differences to test for the presence of two primary tumors. Primary tumors, metastases, and normal tissues were microdissected from formalin-fixed, paraffin-embedded tissues. PCR amplification was performed for microsatellite dna markers on chromosome 17q and 11q13. The colonic tumors were moderately and poorly differentiated, invasive, nonmucinous adenocarcinomas, whereas one uterine tumor was endometrioid adenocarcinoma and the other was papillary serous carcinoma. Although microsatellite instability, as evidenced by changes in the lengths of the amplified PCR products, was detected at 17q and 11q13 loci in the uterine and colonic neoplasms, the patterns of instability differed between the two primary tumor sites. Moreover, the lymph node metastasis in one colonic tumor had genetic alterations that differed from that of the primary tumor. In both patients, the molecular studies suggested the presence of two synchronous primary tumors. Molecular techniques may assist in distinguishing two separate primaries by determining the contraction and expansion of microsatellite regions in dna obtained by microdissection from the primary tumors and associated metastases.- - - - - - - - - - ranking = 1keywords = fallopian tube, tube (Clic here for more details about this article) |
2/18. Effective treatment of a patient with a high-grade endometrial stromal sarcoma with an accelerated regimen of carboplatin and paclitaxel.The rarity of endometrial stromal sarcoma (ESS) and its poor response to treatment provides fertile ground for investigational therapies. An accelerated regimen of carboplatin and paclitaxel is investigated. A patient with a recent history of treated tuberculosis of the lung represented with infertility and acute abdominal pain from suspected fibroids, and underwent a laparotomy with a diagnosis of a high-grade ESS. A novel therapeutic approach using a regimen of carboplatin and paclitaxel with the reinfusion of filgrastim-mobilized peripheral blood progenitor cells is described. A partial response was observed following six cycles of chemotherapy. Grade IV thrombocytopenia occurred after the last cycle, with recovery prior to pelvic radiotherapy. The patient remained well 1 year post-diagnosis. High-grade ESS is responsive to combination chemotherapy with paclitaxel and carboplatin, and requires further evaluation. The use of an accelerated regimen may also have contributed to the response and this question awaits randomized trials.- - - - - - - - - - ranking = 0.0042810494784386keywords = tube (Clic here for more details about this article) |
3/18. Primary endometrioid adenocarcinoma with coexisting endometrial tuberculosis. A case report.BACKGROUND: The most important cause of postmenopausal bleeding is endometrial cancer, whereas genital tuberculosis is uncommon in this age group. The association of these two disorders is extremely rare. CASE: Endometrial curettings performed on a 63-year-old woman with a bloody vaginal discharge and thickened endometrium disclosed complex atypical hyperplasia and granulomatous inflammation with caseation necrosis. The uterus contained a well-differentiated endometrial adenocarcinoma with squamous differentiation invading about one-half the myometrial thickness and granulomatous inflammation with caseation necrosis. The lymph nodes were free of disease. CONCLUSION: Although the coexistence of endometrial cancer and tuberculosis is extremely rare, it may occur in patients who live in the regions with a high prevalence of tuberculosis.- - - - - - - - - - ranking = 0.02996734634907keywords = tube (Clic here for more details about this article) |
4/18. Multiparameter flow cytometry in the diagnosis of a gynaecologic double tumor: a case report.PURPOSE. An uncommon clinical presentation of metastatic tumor will often lead to additional diagnostic examinations. The patient of the present study was known to have endometrial cancer which was thought to be limited to the endometrium. Three months postoperatively, she developed ascites due to spread of the tumor, which is rarely seen in low-stage endometrial cancer. METHOD. Multiparameter flow cytometry using both cell phenotype information and dna ploidy was performed. RESULTS. Retrospectively, the patient was diagnosed as having a dna-diploid epithelial tumor of the endometrium as well as a dna-aneuploid epithelial tumor in the left fallopian tube. It was shown that 3 months after primary surgery she developed ascites caused by metastatic tumor from the primary fallopian tube cancer. CONCLUSION. The complete diagnosis was made using multiparameter flow cytometry which, at present, is not routinely applied in gynecologic pathology.- - - - - - - - - - ranking = 2keywords = fallopian tube, tube (Clic here for more details about this article) |
5/18. Intraepithelial G3 adenocarcinoma of the endometrium after tamoxifen treatment.CASE REPORT: In this paper we describe a case of endometrial carcinoma observed in a post-menopausal patient who was treated with tamoxifen for 5 years after a mastectomy for cancer. She came to our department because of vaginal bleeding 2 years after the end of tamoxifen treatment.TREATMENT: She underwent hysteroscopy and a D and C. A polypoid endometrium completely filled the uterine cavity and was carefully removed by curettage; histology showed a highly undifferentiated neoplasia with a component of serous adenocarcinoma, which was likely to originate from endometrial polyps.OUTCOME: The patient underwent radical hysterectomy, but no residual tumor was found in the uterus or in the tubes, ovary, or pelvic nodes, in spite of its low differentiation grade and high potential aggressiveness, and even though the patient was already symptomatic. Two years after surgery the patient is disease free, which is consistent with the evaluation of the surgical specimen, but unusual in poorly differentiated neoplasms.- - - - - - - - - - ranking = 0.0042810494784386keywords = tube (Clic here for more details about this article) |
6/18. Endometrial adenocarcinoma presenting in a premenopausal patient with tuberous sclerosis.BACKGROUND: Endometrial adenocarcinoma is very uncommon in women under 40 years of age. CASE: A 39-year-old woman with tuberous sclerosis and severe intellectual disability presented with irregular bleeding unresponsive to oral contraceptive therapy. She was subsequently found to have a deeply invasive endometrial adenocarcinoma. CONCLUSION: caregivers must pay particular attention to signs and symptoms in non-verbal patients. Persistent irregular bleeding on oral contraceptive therapy warrants additional evaluation.- - - - - - - - - - ranking = 0.021405247392193keywords = tube (Clic here for more details about this article) |
7/18. Pseudo-Meig's syndrome with multiple synchronous benign and malignant pelvic tumors.BACKGROUND: Meig's and Pseudo-Meig's syndromes have been reported in association with several malignancies but the concomitant existence of multiple synchronous benign and malignant tumors in association with Pseudo-Meigs' syndrome has not been reported in the published literature. CASE: A 55-year old African American woman presented with mild asthma exercebation, right ovarian mass, hydrothorax and elevated CA-125 levels. Histological examination confirmed a right ovarian carcinoid tumor embedded within a mature cystic teratoma while the left ovary, fallopian tube and the uterus contained a poorly differentiated adenocarcinoma of the endometrium. CONCLUSION: This is the first case report of Pseudo-Meig's syndrome in association with ovarian carcinoid tumor and multiple synchronous benign and malignant pelvic tumors.- - - - - - - - - - ranking = 1keywords = fallopian tube, tube (Clic here for more details about this article) |
8/18. Long-term prevention of skeletal complications by pamidronate in a patient with bone metastasis from endometrial carcinoma: a case report.INTRODUCTION: Bisphosphonates are an effective treatment for bone metastases from breast cancer. However, it is unclear whether they are effective for bone metastases from endometrial carcinoma. CASE: A 70-year-old woman previously treated for endometrial carcinoma was referred to our hospital due to osteolytic destruction of the left ischial tuberosity. technetium-99m-HMDP bone scintigraphy revealed abnormal uptake in the ischium. biopsy revealed a metastatic bone tumor, but computed tomography scans did not show general metastatic spread. The patient received intravenous administration of pamidronate and three cycles of chemotherapy (epirubicin paclitaxel carboplatin). Three years later, the bone lesion showed prominent sclerotic changes with no evidence of disease recurrence radiologically. CONCLUSION: Pamidronate may prevent skeletal complications in selected patients with bone metastasis due to endometrial carcinoma.- - - - - - - - - - ranking = 0.0042810494784386keywords = tube (Clic here for more details about this article) |
9/18. Numerical chromosome abnormalities associated with early clinical stages of gynecologic tumors.Cytogenetic data are presented for 12 ovarian, three endometrial, and one fallopian tube tumors. In 15 of these, primary tumors were analyzed and in one ascites was studied. All specimens were obtained at the time of diagnostic surgery. trisomy for chromosome 7 was detected in three ovarian and one endometrial tumors. In one case, trisomy 7 was the sole cytogenetic abnormality detected. Three of the four patients with trisomy 7 had early stages of adenocarcinoma. The data suggest that numerical chromosome abnormalities may be common in borderline and in less aggressive gynecologic tumors.- - - - - - - - - - ranking = 1keywords = fallopian tube, tube (Clic here for more details about this article) |
10/18. 'Minimal deviation' endometrioid carcinoma with oncocytic change of the endometrium.We report an unusual adenocarcinoma of the endometrium in an 80-year-old woman. The tumor diffusely involved the entire thickness of the myometrium. The cervix, ovaries, and fallopian tubes were unremarkable. Microscopic examination revealed an extremely well-differentiated endometrioid adenocarcinoma with mild cytologic atypia and slightly distorted glands infiltrating almost the entire thickness of the myometrium. In addition, the neoplastic endometrioid cells showed extensive oncocytic change. Endometrial curettings had been interpreted as simple endometrial hyperplasia with eosinophilic metaplasia. The significance of this lesion is discussed in terms of possible confusion with benign endometrial lesions as well as benign cervical lesions.- - - - - - - - - - ranking = 1keywords = fallopian tube, tube (Clic here for more details about this article) |
| | Next -> |