1/13. Candida endocarditis treated with a combination of antifungal chemotherapy and aortic valve replacement.A case of candida albicans endocarditis is described in which treatment with 5-fluorocytosine was started after aortic valve replacement, but relapse followed discontinuance of treatment. At a second operation the aortic valve was replaced under 5-fluorocytosine cover and treatment was continued with both 5-fluorocytosine and amphotericin-B. No resistance to 5-fluorocytosine developed, and the candida infection was eradicated. The patient is well 22 months after his operation.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
2/13. Successful medical treatment of candida albicans in mechanical prosthetic valve endocarditis.Fungal prosthetic valve endocarditis is particularly serious, and is usually a result of nosocomial candidaemia. This report describes a patient with candida albicans prosthetic valve endocarditis in whom surgery was believed to be contraindicated. After 45 d of amphotericin b, treatment was continued with fluconazole daily with a follow-up of 16 months, with no recurrent or adverse effects.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
3/13. A case of candida albicans endocarditis 3 years after an aortic valve replacement. Successful combined medical and surgical therapy.The authors report a case of candida albicans endocarditis occurring 3 years after aortic valve replacement and bacterial endocarditis. They may attempt to the difficulty of the diagnosis, the successful combined surgical and medical treatment, the duration and the follow-up of the therapy and finally the aspect of the side effects of the used antifungal drugs.- - - - - - - - - - ranking = 5keywords = candida (Clic here for more details about this article) |
4/13. fluconazole treatment of catheter-related right-sided endocarditis caused by candida albicans and associated with endophthalmitis and folliculitis.An unusual case of catheter-related right-sided endocarditis, endophthalmitis, and extensive folliculitis, apparently caused by a single dna biotype of Candida albicans, was successfully treated with a 6-month course of fluconazole plus two intravitreous doses of amphotericin b. The patient was a 21-year-old man who underwent colectomy for diffuse polyposis and developed the clinical syndrome just described following total parenteral nutrition for the treatment of purulent anal fistulas. fluconazole was initially administered at a daily dose of 200 mg, with 600 mg daily given after 4 weeks. Clinical improvement resulted, with no relapse during 14 months of follow-up. Sequential measurements by an enzyme-linked immunosorbent inhibition assay demonstrated that levels of circulating mannoprotein antigen of C. albicans fell from 75 ng/mL to less than 1 ng/mL after the institution of fluconazole therapy. These observations seem to confirm previous reports on the efficacy of fluconazole as sole therapy for candidal endocarditis and suggest a role for serological studies in clinical monitoring of severe candidal infections.- - - - - - - - - - ranking = 2keywords = candida (Clic here for more details about this article) |
5/13. Survival of candida sepsis in extracorporeal membrane oxygenation.OBJECTIVE: To report the survival of fungal sepsis in extracorporeal membrane oxygenation. DESIGN: Single case report. SETTING: Tertiary referral children's hospital pediatric intensive care unit. patients: A single case report of an infant with congenital heart disease who developed candida sepsis while supported postoperatively with extracorporeal membrane oxygenation. RESULTS: This infant survived a prolonged episode of candidemia after repair of congenital heart disease, which required extracorporeal membrane oxygenation support. The patient has no identified sequelae at 6-month follow-up and continues on long-term fluconazole therapy for candida endocarditis. CONCLUSIONS: candidemia, particularly candida albicans species, may not be a contraindication for extracorporeal membrane oxygenation support. With antifungal therapy and adequate inotropic use to counter the effects of septicemia, survival can be maintained until the patient adequately recovers, allowing decannulation, removal of all catheters, and eventual bloodstream sterility.- - - - - - - - - - ranking = 6keywords = candida (Clic here for more details about this article) |
6/13. Candida endocarditis in neonates: report of five cases and review of the literature.Candidal endocarditis is an uncommon and serious complication of invasive Candida infection in neonates. The aim of this study was to further characterise candidal endocarditis in neonates. Between 1995 and 2000, 56 patients were diagnosed with Candida bloodstream infections (CBSI) in the Neonatal intensive care Unit of Schneider Children's Medical Center of israel. Five of them (9%) developed mycetoma of the right atrium. None of the patients had congenital heart disease or a central venous catheter in the right heart at the time of diagnosis. All were treated with amphotericin b alone or in combination with other antifungals, without surgical intervention. One patient died of the disease and one died later of polymicrobial sepsis and necrotizing enterocolitis. A review of the literature since 1980 yielded an additional 25 cases of candidal endocarditis. For the whole sample (n = 30) survival rate was 73.1%. Six of the 10 patients treated with antifungal agents and surgery survived (60%), compared with 13 of the 20 patients treated only medically (65%) (P = 1.0). Candida endocarditis in neonates differs from fungal endocarditis in adults in risk factors, clinical presentation and outcome. As the outcome of surgical and medical treatment are comparable, antifungal therapy alone may be a valid therapeutic option in high-risk cases.- - - - - - - - - - ranking = 2keywords = candida (Clic here for more details about this article) |
7/13. Survival after rupture of the oesophagus and subsequent candidal endocarditis: use of new serological methods in management.The prognosis following both spontaneous rupture of the oesophagus (Boerhaave's syndrome) and candidal endocarditis is poor. Antifungal treatment for the latter has, in the past, been empirical. A patient who survived both these conditions is described, his case demonstrating some of the major risk factors for candidal endocarditis. Management of his antifungal treatment was guided by newly developed serological methods. Close liaison between microbiologist and clinician is essential for the management of this serious condition.- - - - - - - - - - ranking = 6keywords = candida (Clic here for more details about this article) |
8/13. rupture of a pulmonary artery mycotic aneurysm associated with candidal endocarditis.Candidal endocarditis can develop if candidemia occurs during Swan-Ganz catheterization. Candida endocarditis may persist for many months and is fatal unless the infected valve is resected. Herein is reported the first case of rupture of a mycotic pulmonary artery aneurysm caused by chronic candidal endocarditis. The endocarditis followed Swan-Ganz catheterization and aneurysm progressed despite appropriate medical and surgical therapy.- - - - - - - - - - ranking = 5keywords = candida (Clic here for more details about this article) |
9/13. Candida endocarditis after heart valve replacement (successful management with reoperation and local disinfection).Two patients with candida infection on prosthetic valves are presented. Both were eventually cured after removal of the prosthesis, sterilization of the prosthetic bed with local iodine solution (Sol. Iodi Aethanolica 6.5%) and insertion of a new prosthesis and the discontinuance of antifungal therapy. This technique has subsequently been applied to 22 patients with bacterial endocarditis with good results.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
10/13. Long-term suppressive therapy for Candida parapsilosis-induced prosthetic valve endocarditis.Prompt valve replacement is advocated in patients in whom candidal prosthetic valve endocarditis develops. Unfortunately, some patients with this condition are considered nonsurgical candidates, and they are unable to tolerate long-term administration of amphotericin b with or without flucytosine. Herein we describe a patient with Candida parapsilosis-induced prosthetic valve endocarditis in whom oral administration of fluconazole during an 11-month period successfully suppressed the fungal infection. Three previously published cases indicate that long-term noncurative suppressive therapy for C. parapsilosis-induced prosthetic valve endocarditis may allow prolonged symptom-free survival for such patients.- - - - - - - - - - ranking = 2keywords = candida (Clic here for more details about this article) |
| | Next -> |