1/5. Spondylodiscitis and epidural abscess due to candida albicans.A 32-year-old woman, addicted to heroin, presented with a dorsal spondylodiscitis due to candida albicans associated with epidural abscess. Antimycotic treatment was successful, and no neurosurgical decompression was necessary. To our knowledge, this is the first case of documented epidural involvement in candidal spondylodiscitis. The diagnosis of candidal spondylodiscitis should be considered in cases of para- or tetraplegia occurring in intravenous drug abusers.- - - - - - - - - - ranking = 1keywords = candida (Clic here for more details about this article) |
2/5. candida albicans spondylodiscitis.Candida spondylodiscitis is a rare complication of a haematogenous dissemination of a candida infection, that usually affects immunocompromised patients. We present a case of a candida albicans spondylodiscitis in a patient in whom a bacterial origin was suspected because of the antecedent of a staphylococcus aureus bacteriaemia. After unfavourable evolution with initial antibiotic treatment, the correct diagnosis was reached after culture of the material obtained from surgical debridement. The clinical, diagnostic features, and the literature are reviewed.- - - - - - - - - - ranking = 0.5keywords = candida (Clic here for more details about this article) |
3/5. Candida spondylodiscitis and epidural abscess: management with shorter courses of anti-fungal therapy in combination with surgical debridement.epidural abscess associated with candidal spondylodiscitis is rarely seen, particularly when it involves the cervical and thoracic spine. We report two such cases that were successfully managed with early surgical debridement, as well as medical therapy with intravenous amphotericin followed by oral fluconazole. The literature related to candidal spinal infection is reviewed, and a rational approach to the management of this uncommon condition is proposed. A good outcome may generally be expected with early diagnosis as well as appropriate surgical and pharmacological treatment. Oral fluconazole appears to be useful in the management of candida spondylodiscitis complicated by epidural abscess formation. Treatment until a normal ESR is attained is ideal, and this may be as short as 3 months when surgical drainage has been adequately performed.- - - - - - - - - - ranking = 1.5keywords = candida (Clic here for more details about this article) |
4/5. Intervertebral diskitis due to candida tropicalis.This report describes a case of candida tropicalis intervertebral diskitis successfully treated with a brief course of amphotericin b followed by a longer course of ketoconazole. candida tropicalis is an increasingly frequent pathogen in immunocompromised patients, and infection can become manifest weeks or months after an episode of neutropenia has resolved. The excellent response we observed in this patient adds to a growing body of clinical experience testifying to the effectiveness of ketoconazole in treating certain deep-seated candidal infection.- - - - - - - - - - ranking = 0.5keywords = candida (Clic here for more details about this article) |
5/5. Spondylodiskitis due to candida albicans: report of two patients who were successfully treated with fluconazole and review of the literature.We report the cases of two patients with spondylodiskitis due to candida albicans who were successfully treated with fluconazole. On the basis of findings from these cases and a review of 52 mycologically proven cases in the literature, we describe the main characteristics of candidal spondylodiskitis. In 60% of the cases, candidal spondylodiskitis was a late complication of candidemia (mean delay, 5.2 months) it was determined to be a complication on the basis of the results of previously positive blood cultures (19 cases), and it was presumed to be a complication in iv drug addicts (12 cases). As spondylodiskitis can be a late complication of candidemia, all episodes of candidemia should be treated with systemic antifungal agents. Clinical and radiological signs of candidal spondylodiskitis were nonspecific. Any bone or joint symptoms in a patient who has had candidemia should be considered to be of fungal origin at the time of presentation. The definitive diagnosis of candidal spondylodiskitis was made on the basis of the results of percutaneous puncture in 26 of 30 cases. The overall prognosis for patients with candidal spondylodiskitis was good, with the full recovery rate ranging from 67% to 100%. The preliminary results of treating candidal spondylodiskitis with triazole derivatives, particularly fluconazole, were satisfactory; there was excellent tolerance of this drug.- - - - - - - - - - ranking = 3keywords = candida (Clic here for more details about this article) |