1/10. glucose-6-phosphate dehydrogenase deficiency-induced hemolysis in newly diagnosed diabetic monozygotic twins.A pair of monozygotic male twins are described who manifested hemolysis at the concurrent onset of diabetes type 1. hemolysis appeared progressively following the correction of hyperglycemia and ketoacidosis (one twin). It was found to be related to unknown glucose 6-phosphate dehydrogenase (G-6-PD) deficiency. Other causes of hemolysis such as drugs or bacterial infection were excluded. The fall in glucose availability after the correction of hyperglycemia is proposed as a possible explanation for hemolysis.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
2/10. Identification of prevotella in pedal osteomyelitis of a diabetic patient.osteomyelitis in a diabetic patient with a nonhealing foot ulcer, multiple medical conditions, and recurrent hospitalization for antibiotic therapy was found to be associated with gram-negative bacteria prevotella melanginoganica and prevotella melaninoganica hemagglutinating variant. Those organisms were identified due to the morphologically distinct features in electron microscopy and sequencing of the genes after polymerase chain reaction amplification from the pathological material. The bacteria invaded the bone and resided in osteocyte, osteoblast, and endothelial cells. The bacteria are usually associated with periodontal plaques, causing inflammation and destruction of gingival tissue and resorption of the alveolar bone. This is the first ultrastructural and molecular study of a diabetic bone lesion with anaerobic bacterial infection.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
3/10. autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity.We evaluated a patient with disseminated mycobacterium tuberculosis and mycobacterium chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin g autoantibody to interferon-gamma (IFN-gamma) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-gamma can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy.- - - - - - - - - - ranking = 5keywords = bacterial infection (Clic here for more details about this article) |
4/10. actinomyces as a cause of recurrent perianal fistula in the immunocompromised patient.actinomycosis is an uncommon bacterial infection that has a characteristic chronic indolent course. patients with this infection frequently undergo multiple surgical procedures before a correct diagnosis is made. Perianal actinomycosis should be suspected if a nontender perianal mass is found to contain thin purulent material and small yellow particles (sulfur granules). The diagnosis is confirmed by special stains and anaerobic cultures. Recognition of this infection is important because successful treatment requires combined surgical and antibiotic therapy. We report two patients, one with diabetes mellitus and one with human immunodeficiency virus III, who had recurrent perianal abscesses caused by actinomyces and were treated successfully with surgical drainage and antimicrobial therapy.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
5/10. An unusual finding in scleredema.Scleredema of Buschke is a rare disorder in which areas of induration appear in the skin, commonly after a remote infection and sometimes with diabetes and para-proteinemias. We report an unusual finding in an adult patient of long standing classical scleredema who developed chronic clustered papules/pseudovesicular lesions with koebnerization after a bacterial infection of the upper back.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
6/10. Cutaneous zygomycosis in a diabetic HTLV-I-seropositive man.zygomycosis, an invasive fungal infection, is usually seen in persons with diabetes, particularly in those with diabetic ketoacidosis. The infection most frequently occurs in the rhinocerebral region and rapidly spreads, causing a swift demise. Rarely, the infection is confined to the cutaneous tissues. We describe a 31-year-old man seropositive for human T lymphotropic virus type I who had diabetic ketoacidosis with zygomycosis confined to the right arm. The lesion was presumed initially to be a bacterial infection but did not respond to conventional antimicrobial therapy. The arm lesion was cultured, and rhizopus arrhizus was isolated. The patient responded well to a combination of amphotericin b and extensive surgical debridements. Our case emphasizes the importance of maintaining a high index of suspicion of cutaneous zygomycotic infections in the impaired host, especially of those in patients with diabetes, who do not respond to initial antimicrobial treatment.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
7/10. candida osteomyelitis.Medical care of the hospital patient has become increasingly complicated due to the rising incidence of risk factors for opportunistic infection. With intravenous drug use, hiv infection, and alcoholism complicating an immunocompromised host such as a diabetic, fungal and mycobacterial infections are no longer as rare as in previous reports. The authors present a case of candida osteomyelitis in a patient with multiple risk factors for opportunistic infection.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
8/10. Fatal genitourinary mucormycosis in a patient with undiagnosed diabetes.We present what we believe is the first report in the world literature of penile necrosis due to mucormycosis, a rare and often fatal fungal infection. This case of rhizopus mucormycosis began with a penile lesion in a 27-year-old patient with undiagnosed diabetes; it led to necrosis of the phallus, lower urinary tract, rectum, and pelvic musculature and finally to death. Despite repeated aggressive surgical debridement in conjunction with medical therapy, we were unable to halt the progression of the fungal and synergistic bacterial infections.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
9/10. mucormycosis caused by rhizopus microsporus var. microsporus: cellulitis in the leg of a diabetic patient cured by amputation.mucormycosis accompanied the development of bacterial infection in the leg of a diabetic African-American man. Local injury, diabetic ketoacidosis, renal insufficiency, and antimicrobial therapy were factors that contributed to the pathogenesis of the mucormycosis. The cellulitis was caused in part by rhizopus microsporus var. microsporus and was cured by amputation. We report this unusual case of mucormycosis to emphasize the value of fungal identification, to illustrate a dramatic and successful clinical result, and to draw attention to an apparent role for bacterial infection and its treatment in the pathogenesis of mucormycosis. It is the third case report of mucormycosis in a human in which R. microsporus var. microsporus was definitively identified as the etiologic agent.- - - - - - - - - - ranking = 2keywords = bacterial infection (Clic here for more details about this article) |
10/10. blood glucose normalization-induced haemolysis in three adolescents with type 1 diabetes mellitus at onset and unknown G-6-PD deficiency.We present three adolescents unknown to be G-6-PD deficient who developed haemolytic anaemia after admission for diabetes at onset uncomplicated by ketoacidosis. These patients had no bacterial infections and had not ingested haemolytic drugs. The fall in glucose availability after the correction of hyperglycaemia is proposed as capable of inducing haemolysis in G-6-PD deficiency.- - - - - - - - - - ranking = 1keywords = bacterial infection (Clic here for more details about this article) |
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