1/8. mycosis fungoides presenting as Ofuji's papuloerythroderma.We report three patients presented with clinical features of Ofuji's papuloerythroderma (pruritic erythematous papules and extensive erythema sparing all skin folds), however, showing histopathological findings of mycosis fungoides (Pautrier's microabscess, haloed lymphocytes, disproportionate epidermotropism, and wiry collagen bundles). One case was associated with plaque stage of mycosis fungoides and follicular mucinosis. T-cell receptor (TCR) gene rearrangement analysis in the lesional skin tissue demonstrated rearrangement of the gamma chain in all cases. HTLV-1 serology was negative for two patients who conducted HTLV-1 test.We think that Ofuji's papuloerythroderma might be a variant of early mycosis fungoides rather than secondary skin manifestations to certain cutaneous inflammatory diseases.- - - - - - - - - - ranking = 1keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
2/8. A case of T-cell lymphoma with Sezary cells in the blood and bone marrow accompanied by peripheral T and B lymphocytosis.A case of T-cell lymphoma occurred in a man, aged 66, whose symptoms started as itching and the appearance of 1-2 cm indurated plaques with central pustules on the skin of the trunk and face. A few months later generalized lymphomas and splenomegaly were present. Investigations of the lymphocytic subpopulations in situ in fresh frozen sections of lymphomas and skin showed only T cells. Samples of blood and bone marrow disclosed lymphocytosis and Sezary cells. Both T and B lymphocytes were definitely increased in the blood. The value of tissue studies in analyzing lymphocytic subpopulations is emphasized as a differential diagnostic aid in classifying lymphomas. A relationship between the T-cell neoplasia and the T and B lymphocytosis to mycosis fungoides and the sezary syndrome is discussed.- - - - - - - - - - ranking = 0.32535933047912keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
3/8. Electron-beam therapy for mycosis fungoides.The lesions of mycosis fungoides are radiosensitive and because extensive areas of the body are usually involved, the treatment of choice is with the electron beam. Since 1971, a fractionation scheme of weekly doses for irradiation of the entire skin surface has been practiced with a 6 MeV linear accelerator that generates 3.5 MeV electrons. One hundred and five patients were treated in this way by delivering 400 rads once weekly for six consecutive weeks. All patitents enjoyed complete disappearance of the skin lesions at once. Of the 62 patients whom we were able to follow-up after electron-beam therapy, for periods ranging from one to nearly seven years (median, two years), the duration of remission was one-half to nearly five and a half years (median, one and one-half years). The treatment was well tolerated and no unusual skin reactions or hematopoietic depression occurred.- - - - - - - - - - ranking = 1.6267966523956keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
4/8. Coexistence of pemphigus foliaceus and mycosis fungoides.mycosis fungoides was documented in a patient two years after pemphigus foliaceus had been diagnosed and treated with corticosteroids. Eight years later, the patient was found to have stage IV lymphomatous disease with generalized erythroderma and palpable, histologically positive lymph nodes. hematoxylin-eosin staining of a specimen of erythroderma revealed mycosis fungoides, while direct immunofluorescence of this tissue revealed intercellular IgG deposits diagnostic of pemphigus foliaceus.- - - - - - - - - - ranking = 1.6921828241607keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
5/8. An aggressive spindle cell squamous carcinoma arising in a patient with long-standing erythroderma.Spindle cell squamous carcinoma (SCSC) of the left hand arising in a patient with long-standing erythroderma is reported. Histopathologically, spindle shaped atypical cells were observed neighboring the cells of well differentiated squamous cell carcinoma. These two types of tumor cells, spindle cells and well differentiated cells, were present side by side and merged into each other. The erythroderma had been present for over 20 years, and both clinical and histopathological findings suggested cutaneous T cell lymphoma, but were not diagnostic for mycosis fungoides, sezary syndrome, or adult T cell lymphoma. flow cytometry of peripheral blood cells showed a low CD4/CD8 ratio which suggested impaired T cell function. Multiple metastases of SCSC occurred in a short period and the patient died ten months after his first visit to us. The aggressive course of this case was unusual, and may be due to immunological abnormalities associated with the long standing erythroderma with impaired T cell function.- - - - - - - - - - ranking = 0.32535933047912keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
6/8. Ofuji papuloerythroderma associated with follicular mucinosis in mycosis fungoides.Ofuji papuloerythroderma is a distinctive clinical entity of unknown etiology, which may occasionally be associated with B cell and T cell lymphoma or visceral malignancy. We report a case of papuloerythroderma associated with follicular mucinosis in mycosis fungoides (MF) that raises the possibility of papuloerythroderma as a form of prelymphomatous skin eruption. This specific papuloerythroderma responded well to the Re-PUVA treatment, which is a combination of etretinate and PUVA photochemotherapy.- - - - - - - - - - ranking = 1.6267966523956keywords = mycosis fungoides, fungoides, mycosis (Clic here for more details about this article) |
7/8. Cutaneous adverse effects associated with terbinafine therapy: 10 case reports and a review of the literature.Terbinafine is an allylamine antifungal agent widely used to treat dermatophyte onychomycosis and dermatomycoses. We report 10 severe cutaneous adverse reactions associated with terbinafine therapy which required discontinuation of the antifungal agent: erythema multiforme (five patients), erythroderma (one), severe urticaria (one), pityriasis rosea (one) and worsening of pre-existing psoriasis (two patients). The spectrum of cutaneous adverse effects associated with terbinafine therapy is reviewed. patients should be counselled about discontinuing terbinafine at the onset of a cutaneous eruption and about seeking medical advice about further management.- - - - - - - - - - ranking = 0.022350480215993keywords = mycosis (Clic here for more details about this article) |
8/8. mycosis fungoides in young patients: clinical characteristics and outcome.BACKGROUND: mycosis fungoides (MF) can begin as early as the first decade of life. Few studies have reviewed MF in younger patients and none has been large enough to assess prognosis and outcome. OBJECTIVE: We reviewed the clinical characteristics, prognosis, factors related to disease progression, and therapy in patients with MF younger than 35 years of age. methods: Fifty-eight patients were entered into this retrospective cohort analysis. Results: Significantly fewer patients with MF who are younger than 35 years presented with erythroderma (T4) and more with limited patch/plaque (T1) disease than older patients. Duration of skin disease before diagnosis of MF did not vary between the two groups. The long-term survival of younger patients with MF is significantly decreased when compared with a race-, age-, and sex-matched control population (p < 0.001). Disease-specific survivals (DSS) of younger and older patients are similar, but young patients show a slight but significantly better overall DSS (p < 0.02). However, DSS comparison of generalized patch/plaque (T2) and tumor stage (T3) patients with MF showed no significant difference between young and old patients (p=0.47, p=0.59). Patient age was not a significant predictor of survival when controlled for T-stage. Sixteen of 58 young patients with MF have died, 13 because of MF (22%), compared with 138 of 500 older patients (28%) who died as a result of MF. All younger patients with MF who progressed had at least T2 disease at presentation. Fifty of 56 young patients with MF and T1-T3 disease were treated initially with total skin electron beam or topical nitrogen mustard. The response to therapy was similar in younger and older patients with MF. CONCLUSION: T1 disease is more common and T4 disease is unusual in young patients with MF compared with an older population of patients with MF. Young patients with T1 disease, all of whom were treated with either topical nitrogen mustard or total skin electron beam therapy, or both therapies, showed no disease progression. overall, young patients with MF showed slightly better DSS, but this was because of differences in stage distribution.- - - - - - - - - - ranking = 0.32693085882577keywords = fungoides (Clic here for more details about this article) |