1/14. Alantolactone sensitivity in chrysanthemum contact dermatitis.A case of occupational chrysanthemum contact dermatitis is reported. patch tests showed the patient to be sensitized to chrysanthemum morifolium (Chr M) leaves, flowers, and stems (alcoholic extracts) and to alantolactone. An attempt at desensitization appears to have been successful. Gas chromatography indicated the presence of alantolactone in all the various parts of Chr M, mostly in the flowers. The "maximization test" succeeded in sensitizing guinea pigs to alantolactone.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
2/14. Facial dermatitis caused by chlorothalonil in a paint.A case of acute facial dermatitis caused by staying in a summer cottage is described. Patch testing revealed contact allergy to the paint Pa Tra Lasur, and to chlorothalonil. Chlorothalonil was used as a pesticide in the paint. Chemical analyses using high-performance liquid chromatography and gas chromatography/mass spectrometry were performed to reveal the purity of the chlorothalonil. Chlorothalonil has earlier been described as a contact allergen, sometimes causing facial dermatitis. The reason for localization to the face has not before been discussed. It is now suggested that it might be due to the high vapour pressure of chlorothalonil. It is concluded that products containing chlorothalonil are unsuitable for indoor use.- - - - - - - - - - ranking = 2keywords = chromatography (Clic here for more details about this article) |
3/14. Allergic contact sensitivity to quinophthalone.A 73-year-old patient, diagnosed as having seborrheic dermatitis, was patch tested with his hair preparations. The hair stick gave a positive reaction. Among its ingredients, D & C Yellow No. 11, from 0.0001% to 0.1%, and perfume showed positive reactions. D & C Yellow No. 11 was found to consist only of quinophthalone by chemical analyses. The concentration of quinophthalone in the hair stick was determined as 9.41 ppm w/w by high-performance liquid chromatography.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
4/14. Contact allergy to the UV-absorber Tinuvin P in plastics.Contact allergy to the UV-absorber 2-(2-hydroxy-5-methylphenyl)benzotriazole (Tinuvin P) was revealed in a patient with wrist dermatitis caused by a plastic watch strap. A high-performance liquid chromatography method was developed and subsequent chemical analysis showed the presence of Tinuvin P in the watch strap. The possibility of cross-reactions between Tinuvin P and various substituted benzotriazole compounds was investigated. No cross-reactions were found.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
5/14. Occupational dermatitis due to an epoxy acrylate.A dental assistant developed sensitivity to dental restorative materials within 3 months of starting to use them. They contained the epoxy acrylate BIS-GMA, which is the most commonly used dimethacrylate monomer in dental composite restorations. She was positive to a patch test with BIS-GMA, which was the probable allergen, and epoxy resin, but this substance was not present in the materials used, as shown by high performance liquid chromatography. The patient was also allergic to the disinfectant Desimex i containing dodecyl diaminoethyl glycine.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
6/14. Lipstick dermatitis due to C18 aliphatic compounds.An 18-year-old girl developed cheilitis. She had a past history of lip cream dermatitis, but the cause was not found. patch tests with 2 lipsticks were strongly positive. Tests with the ingredients were positive to 2 aliphatic compounds, glyceryl diisostearate and diisostearyl malate. Impurities in the materials were suspected as the cause. Analysis by gas chromatography detected 3 chemicals in glyceryl diisostearate and 1 in diisostearyl malate as impurities. Patch testing with the impurities and glyceryl monoisostearate 0.01% pet in glyceryl diisostearate and isostearyl alcohol 0.25% pet in diisostearyl malate were strongly positive. The characteristics common to the 2 chemicals were liquidity at room temperature, branched C18 aliphatic compound and primary alcohol. Chemicals lacking any of the above 3 features did not react.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
7/14. Is sesamol present in sesame oil?sesame oil has been reported to contain sesamolin, sesamin and sesamol as contact allergens. A female patient had cheilitis due to sesame oil in a lipstick. She reacted to sesamolin and sesamin, but not to sesamol. We carried out analysis of the sesame oil by high performance liquid chromatography. We detected sesamolin and sesamin but not sesamol in sesame oil.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
8/14. Triphenyl phosphate allergy from spectacle frames.A case of triphenyl phosphate allergy from spectacle frames is reported. patch tests with analytical grade triphenyl phosphate, tri-m-cresyl phosphate, and tri-p-cresyl phosphate in the concentrations 5%, 0.5% and 0.05% pet. showed positive reactions to 0.05% triphenyl phosphate and 0.5% tri-m-cresyl phosphate, but no reaction to tri-p-cresyl phosphate. Gas chromatography of the tricresyl phosphate 5% pet. patch test material supplied from Trolab showed that it contained a mixture of a wide range of triaryl phosphates, including 0.08% triphenyl phosphate which is above the threshold for detecting triphenyl phosphate allergy in our patient.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
9/14. Contact allergy to photoproducts of musk ambrette.A patient with photocontact allergy to musk ambrette was investigated with patch and photopatch testing with dilutions of musk ambrette and 4 other nitro-musk compounds (musk ketone, moskene, musk tibetine, musk xylene) as well as with in vitro ultraviolet-irradiated solutions of musk ambrette. Besides a strong photoallergy to musk ambrette, a plain contact allergy to photoproducts of musk ambrette was demonstrated. An attempt to isolate the photoproducts causing the plain contact allergy was performed by using a preparative thin layer chromatography technique. These isolated photoproducts were not, however, responsible for the contact allergy to the photodecomposed musk ambrette.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
10/14. Brilliant Lake Red R as a cause of pigmented contact dermatitis.Twenty-three patients suffering from pigmented contact dermatitis caused by cosmetics containing Brilliant Lake Red R were observed. Commercial samples of Brilliant Lake Red R proved to contain many ethyl acetate extractable impurities; 1-phenylazo-2-naphthol and azobenzene were isolated and identified. To determine the responsible allergens, five patients were examined by patch tests with purified samples of azo-dyes and the unidentified fractions of ethyl acetate extractable impurities. Three out of five showed weaker reactions to purified samples of Brilliant Lake Red R and the other two showed equal reactions compared to the commercial product. 1-Phenylazo-2-naphthol was found to be a strong allergen in all cases but none showed a positive reaction to azobenzene. Some unidentified fractions also gave positive results. patch tests were performed with 4-phenylazo-1-naphthol, 4-phenylazo-1-naphthol-2-carboxylic acid, and 2,4-bis(phenylazo)-1-naphthol, as structurally related compounds derived from 1-naphthol. All gave negative and they were not detected in the ethyl acetate extractable impurities by thin-layer chromatography.- - - - - - - - - - ranking = 1keywords = chromatography (Clic here for more details about this article) |
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