1/62. shock syndrome in primary dengue infections.During 1974, 114 patients with dengue hemorrhagic fever were studied at the Bankok Children's Hospital. Over 40% of the patients had dengue shock syndrome. Five fatal cases were included in the study. Primary dengue infections were identified by absent or low titered antibodies in acute sera and the sequential development of IgM antibodies followed by IgG antibodies during convalescence. Three patients, aged 4,8, and 12 years, had primary dengue infections with shock. Although no convalescent sera could be tested two other patients, aged 7 to 12 years, with fatal disease also appeared to have primary infections. At the time of shock patients with primary infections had subnormal concentrations of complement factor 3. The data show that in older children dengue shock syndrome associated with complement depression can occur during primary as well as secondary infections.- - - - - - - - - - ranking = 1keywords = infection (Clic here for more details about this article) |
2/62. Report of a fatal case of dengue infection with hepatitis: demonstration of dengue antigens in hepatocytes and liver apoptosis.A fatal case of dengue (DEN) infection associated with a spleen rupture and with hepatitis is reported here. Microscopic studies showed numerous areas of spleen rupture with hematomas and revealed necrotic foci in liver samples obtained at autopsy. Although hepatitis was reported in several cases of DEN fever, the mechanism of liver injury remains poorly understood. In this case, immunohistochemistry showed that DEN viral antigens were mostly detected in hepatocytes surrounding the necrotic foci. By in situ detection of dna fragmentation, apoptotic hepatocytes were found to be colocated with DEN virus-infected hepatocytes. These findings suggest that hepatocytes are the major sites of DEN virus replication in the liver and that DEN virus induces apoptosis of hepatocytes in vivo.- - - - - - - - - - ranking = 0.55555555555556keywords = infection (Clic here for more details about this article) |
3/62. Dengue infection with unusual manifestations: a case report.Since 1978, there has been an increasing number of reported cases of dengue infection with unusual manifestations and most of them had dengue shock syndrome. We report here one patient who had dengue hemorrhagic fever grade II with liver failure and hepatic encephalopathy and very high elevation of liver enzymes. She made a complete recovery after conservative therapy. She is the fourth case of reported dengue hemorrhagic fever grade II who had unusual manifestation.- - - - - - - - - - ranking = 0.55555555555556keywords = infection (Clic here for more details about this article) |
4/62. Unusual association of Kikuchi's disease and dengue virus infection evolving into systemic lupus erythematosus.Kikuchi's disease is a histologically alarming self-limiting condition typically affecting the lymph nodes of young females. A 13-year-old girl was presented with fever, skin rash and cervical lymphadenopathy. On examination she was found febrile, mild pallor was present and she had lymphadenopathy. Liver was palpable. Cervical lymph node biopsy showed histiocytic necrotising lymphadenitis (Kikuchi's disease). dengue virus serology for IgG blot showed evidence of seroconversion in serial samples. She was treated with antibiotics and fluconazole and cyclosporin A. During hospitalisation she developed retinal vasculitis. She was reviewed after one month and showed rashes of subacute cutaneous lupus erythematosus. This case can be described to be a triggering event by dengue viral infection causing abnormal immune response leading initially to Kikuchi's disease and later on to systemic lupus erythematosus.- - - - - - - - - - ranking = 0.55555555555556keywords = infection (Clic here for more details about this article) |
5/62. brain involvement in Dengue fever.During the 1994-1995 outbreak of dengue fever in new caledonia (1079 cases), two cases of encephalopathy were seen. Both patients suffered transient clinical (drowsiness, confusion) and electroencephalographic disturbances from which they fully recovered. Although this condition has been described in dengue infection a number of different pathological mechanisms are probably implicated.- - - - - - - - - - ranking = 0.11111111111111keywords = infection (Clic here for more details about this article) |
6/62. Using buffy coat for reverse transcriptase-polymerase chain reaction in the diagnosis of dengue virus infection: preliminary study.Using reverse transcriptase-polymerase chain reaction (RT-PCR) to detect and type from viremic human serum samples for dengue virus infection is widely used today. However, a few false-negative results were reported due to very low titers of the virus particle in serum samples. As mononuclear cells, macrophages or monocytes are target cells for dengue virus infection, and the replication of virions can be observed in peripheral leukocytes frequently, the amount of virus particle in buffy coat should be higher than those in serum samples. Here, we describe a procedure in which rna extraction from the buffy coat of a patient with a false-negative serum sample yielded specific viral rna amplifiable by RT-PCR, thereby providing an alternative choice for the accurate diagnosis of dengue infection.- - - - - - - - - - ranking = 0.77777777777778keywords = infection (Clic here for more details about this article) |
7/62. Arbovirus studies in two towns in western state of nigeria.Three hundred and fifty-one persons were tested for HI antibody to arbovirus Groups A, B and Ingwavuma viruses in Ilesha and Oshogbo, two towns in western nigeria. Chikungunya accouted for most Group A infections (39%). antibodies to Group B virus were distributed as follows: Dengue 22%, yellow fever 25%, West Nile 28% and Wesselsbron 30%. Few sera 5% were positive to Ingwavuma. No virus was isolated from 188 blood specimens processed for virus isolation.- - - - - - - - - - ranking = 0.11111111111111keywords = infection (Clic here for more details about this article) |
8/62. Acute myeloid leukemia precipitated by dengue virus infection in a patient with hemoglobin h disease.We report a unique case of refractory acute myeloid leukemia (AML) precipitated by dengue virus induced marrow aplasia in a Chinese patient with hemoglobin (Hb) H disease. The quick temporal sequence of the three marrow abnormalities: hereditary hemoglobinopathy, reactive viral induced marrow change and malignant neoplastic process is highly unusual. Neither HbH disease nor viral induced marrow aplasia has known associations with AML. We propose that this unique case of AML may be caused by cytokine hyperstimulation in a stressed marrow.- - - - - - - - - - ranking = 0.44444444444444keywords = infection (Clic here for more details about this article) |
9/62. Prenatal transmission of dengue: two new cases.Dengue is commonly observed in most tropical countries, but its transmission from mother to fetus has not been frequently described. We report two such cases. The first signs of dengue in the infants appeared on the 3rd and 9th days of life. In both, a bacterial infection was suspected initially. In areas where it is endemic, the diagnosis of dengue should be considered in the neonate with signs of bacterial infection. When dengue is suspected in a pregnant woman, laboratory investigation and extended observation of the newborn are advised.- - - - - - - - - - ranking = 0.22222222222222keywords = infection (Clic here for more details about this article) |
10/62. Dengue fever in the czech republic.BACKGROUND: Dengue fever has become, in Western europe, the second most frequently imported disease after viral hepatitis a. OBJECTIVES: Dengue fever was diagnosed at the Department of Infectious disease, University Hospital in Brno, so the authors decided to make local physicians aware of the possibility of the disease being contracted by Czech travelers. methods: The first two cases of dengue fever, with the patients hospitalized at the Department of Infectious disease, University Hospital in Brno, czech republic, are described. RESULTS: A young couple contracted this infection in a region usually visited by tourists in thailand. The disease broke out 12 hours after their return home. The clinical and laboratory pictures of the disease and the kinetics of serological responses are described in detail. CONCLUSION: The chief diagnostic clue with this disease, beside a visit to a high-risk area, can be considered a sudden onset of fever accompanied by marked fatigue, myalgia, and arthralgia. Laboratory tests showed characteristic thrombocytopenia, leukopenia, and pathological values of AST and ALT. The clinical picture is characterized by symptoms of persisting fatigue and exhaustion, even after the fever has subsided.- - - - - - - - - - ranking = 0.11111111111111keywords = infection (Clic here for more details about this article) |
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