1/6. Interstitial cystitis and ileus in pediatric-onset systemic lupus erythematosus.A girl aged 11 years presented with autoimmune hemolytic anemia with thrombocytopenia, and subsequently developed severe abdominal pain, vomiting, and pollakiuria. X-ray findings of her abdomen demonstrated paralytic ileus with intestinal wall thickening. Intravenous pyelography revealed bilateral hydroureter with mild hydronephrosis and contracted bladder. Pathological examination of her bladder revealed interstitial cystitis, with evidence of focal deposition of IgG and C3 in a granular pattern on small blood vessel walls. She was diagnosed as having systemic lupus erythematosus (SLE) associated with paralytic ileus and chronic interstitial cystitis. Although initiation of high-dose prednisolone therapy resulted in a gradual improvement in clinical symptoms, reducing the dosage of prednisolone caused a relapse. To our knowledge, the combination of paralytic ileus and chronic interstitial cystitis is quite uncommon in pediatric-onset SLE.- - - - - - - - - - ranking = 1keywords = lupus erythematosus, erythematosus, systemic lupus erythematosus, lupus, systemic lupus (Clic here for more details about this article) |
2/6. A case of lupus cystitis diagnosed from urinary symptoms as the sole initial complaint.cystitis related with systemic lupus erythematosis (SLE) is termed as lupus cystitis. It is a subtype of SLE in which gastrointestinal and bladder symptoms are prominent and it usually manifests with other symptoms of SLE. We present a case in a 37-year-old woman whose sole complaint was the severe urinary symptoms. A biopsy of the bladder showed inflammation in the submucosa and the finding of vasculitis. An autoimmune disease was suspected from the blood serum sample. A further laboratory study was performed and she was diagnosed with SLE and lupus cystitis. Prompt therapy with corticosteroids resulted in the improvement of the severe bladder symptoms.- - - - - - - - - - ranking = 0.14838502030697keywords = lupus, systemic lupus (Clic here for more details about this article) |
3/6. Systemic lupus erythematosus relapse with lupus cystitis.A 45-year-old woman who had been diagnosed as having systemic lupus erythematosus (SLE) at the age of 28 years and who had been in remission developed severe urinary frequency, watery diarrhea, vomiting and weight loss. She also developed acute renal failure and her serological examination was consistent with active SLE. She had a markedly decreased urinary bladder capacity of 20 ml with hydroureteronephrosis. Histopathological study of her urinary bladder biopsy specimen showed mucosal edema, infiltration by lymphocytes and granulocytes, and deposition of IgA in the epithelium and submucosal region. We diagnosed this as a case of lupus cystitis. The patient's symptoms were alleviated by bilateral nephrostomy and corticosteroid therapy. In the present episode the patient showed none of the usual symptoms of SLE. This case and others reported in the literature show that lupus cystitis presents with specific signs and symptoms and therefore, this syndrome may represent a specific clinical manifestation of SLE.- - - - - - - - - - ranking = 0.96201711409775keywords = lupus erythematosus, erythematosus, systemic lupus erythematosus, lupus, systemic lupus (Clic here for more details about this article) |
4/6. Steroid pulse therapy in lupus cystitis.A middle-aged woman with lupus cystitis showed no other symptoms of lupus vasculitis. Cystoscopic findings revealed mucosal hemorrhage and hyperemia. Histological studies of the bladder showed mucosal edema, inflammatory cellular infiltration and the deposition of immune complexes along the vessels. She was treated with a combination of intravenous methylprednisolone pulse therapy and oral prednisolone. cystoscopy and histological findings showed appreciable improvement. Elevated urinary levels of chemokines such as interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF) decreased during convalescence. These results suggest that the early diagnosis and treatment with steroid pulse therapy achieves improvement of an unusual vasculitis symptom, lupus cystitis.- - - - - - - - - - ranking = 0.14013716772961keywords = lupus (Clic here for more details about this article) |
5/6. Obstructive uropathy due to interstitial cystitis in a patient with systemic lupus erythematosus.A patient with documented SLE is described who presented with dysuria, gastrointestinal (GI) symptoms and renal insufficiency associated with the unusual occurrence of bilateral hydro-ureteronephrosis due to ureterovesical junction stricture (obstructive uropathy) on radiographic findings. Pathologic investigations disclosed chronic interstitial cystitis (IC) with evidence of focal immune complex deposition in blood vessel walls of the bladder. The GI symptoms and dysuria regressed with initial therapy of SLE by steroid but persistent obstructive uropathy (OU) and renal insufficiency required bilateral nephrostomy. Then, following continuous medical treatment with steroid plus intravenous pulse injection of cyclophosphamide, obstructive uropathy was relieved even with removing nephrostomy tube and renal function remained stable.- - - - - - - - - - ranking = 0.8keywords = lupus erythematosus, erythematosus, systemic lupus erythematosus, lupus, systemic lupus (Clic here for more details about this article) |
6/6. Chronic interstitial cystitis and systemic lupus erythematosus in an 8-year-old girl.An 8-year-old girl with systemic lupus erythematosus (SLE) and diffuse proliferative glomerulonephritis had chronic interstitial cystitis (CIC) early in the course of SLE. The early occurrence of CIC, the lack of intestinal symptoms, the association with vesicoureteric reflux, and the improvement of CIC during therapy with cyclosporin A were the prominent features of the patient reported here.- - - - - - - - - - ranking = 1keywords = lupus erythematosus, erythematosus, systemic lupus erythematosus, lupus, systemic lupus (Clic here for more details about this article) |