Cases reported "Corneal Ulcer"

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1/13. Infectious keratitis after photorefractive keratectomy in a comanaged setting.

    A 48-year-old man had simultaneous bilateral photorefractive keratectomy (PRK). The surgeon who performed the PRK did not see the patient in follow-up, and there was confusion regarding the comanaging doctor. Therefore, the patient was not examined immediately postoperatively. Several days later, he was hospitalized for an unrelated, painful orthopedic problem and heavily sedated. Seven days after the PRK, an ophthalmologist was consulted for ocular irritation and discharge. Examination showed bilateral, purulent conjunctivitis and severe infectious keratitis in the left eye. The patient was treated with periocular and topical antibiotics. Corneal cultures yielded staphylococcus aureus. The keratitis resolved slowly, leaving the patient with hand motion visual acuity. A corneal transplant and cataract extraction was performed 15 months later, resulting in a best corrected visual acuity of 20/400 because of glaucomatous optic nerve damage. Severe infectious keratitis may occur after PRK. Poor communication between the surgeon, comanaging doctor, and patient may result in treatment delay.
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2/13. Peripheral ulcerative keratitis after clear corneal cataract extraction(1).

    A previously healthy 80-year-old man had uneventful clear corneal cataract extraction. An extensive peripheral corneal infiltrate with overlying epithelial defect at the incision site was noted at the regular follow-up visit 1 week after surgery. Corneal cultures showed no evidence of infectious keratitis. A systemic evaluation uncovered early-stage, active rheumatoid arthritis. This case illustrates that peripheral ulcerative keratitis may occur with a small clear corneal incision and may be the presenting sign of a previously undiagnosed rheumatoid disease.
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3/13. Mooren's ulcer: two cases occurring after cataract extraction and treated with hydrophilic lens.

    Two patients developed Mooren's ulcer following cataract extraction. The first case was complicated by ocular trauma 8 years prior to surgery and by vitreous loss at the time of surgery. The second patient underwent cataract extraction without complication. Surgical trauma may have been the inciting factor in the development of these ulcers. Both patients experienced dramatic relief of ocular pain following the application of hydrophilic lenses. There was no apparent alteration in the course of the disease in either case. The use of hydrophilic soft lenses is suggested for symptomatic relief of the severe ocular pain experienced by patients with Mooren's ulcer.
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4/13. Sensitive and rapid polymerase chain reaction based diagnosis of mycotic keratitis through single stranded conformation polymorphism.

    PURPOSE: To report a method for early and correct diagnosis of mycotic keratitis. DESIGN: Clinical laboratory diagnostic study. methods: Corneal scraping of all the four patients were processed for dna extraction which were amplified by fungal specific primers of internal transcribed spacer region I (ITS1). These products were sequenced and analyzed by single stranded conformation polymorphism (SSCP) for species identification. RESULTS: The dna samples from corneal scrapings of all the four patients were successfully amplified by the primer pair ITS1 and ITS2 and similarity/dissimilarity were established by Jaccard's coefficient. Patient isolate 1 was identified as nectria hematococca, isolate 2 as candida albicans, and isolates 3 and 4 were identified as Bipolaris papendorfii. This led to prompt initiation of antifungal therapy in all the four cases where useful vision could be restored. CONCLUSIONS: Early and correct diagnosis of mycotic keratitis by polymerase chain reaction could be obtained in all the four cases compared with conventional methods, which helped in the prompt initiation of antifungal therapy in patients.
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5/13. Keratomycotic malignant glaucoma.

    Malignant glaucoma due to Keratomycosis is a devastating and poorly recognised complication occurring in a small percentage of treated patients. It is characterized, in cases of Keratomycosis by a raised tension, uniform shallowing of the anterior chamber and a fungus-exudate-iris mass covering the pupillary area. Three cases of 'Keratomycotic Malignant glaucoma' are discussed here. Two of these were successfully treated with therapeutic keratoplasty, extracapsular lens extraction and systemic antifungals. The development of malignant glaucoma after a therapeutic keratoplasty which occurred in one case has not previously been reported. All the three cases which developed malignant glaucoma had a pupillary size of 4 mm diameter or less and grew fusarium from the cornea and anterior chamber.
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6/13. Sterile corneal ulceration after cataract extraction in patients with collagen vascular disease.

    We report the occurrence of sterile corneal ulceration in 11 eyes of eight patients with collagen vascular diseases and dry eyes after cataract extraction with intraocular lens implantation. Keratolysis occurred after both extracapsular and intracapsular cataract extraction and appeared unrelated to the type of intraocular lens. Despite aggressive lubrication and other medical treatment, including systemic immunosuppressive agents, penetrating keratoplasty was often required. Although all eyes were saved, visual outcome was usually poor. The histopathologic finding of polymorphonuclear leukocytes localized near the areas of corneal dissolution provides evidence for the role of polymorphonuclear leukocyte-derived collagenase as a contributing factor in the pathogenesis of sterile corneal ulceration in these patients.
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7/13. Sterile corneal ulcers after cataract surgery in keratoconjunctivitis sicca.

    Mild keratoconjunctivitis sicca can become dramatically worse after cataract extraction and result in corneal thinning and perforation. Anticipation of this problem can prevent it, but lack of recognition may result in permanent central scarring from ulceration, which responds slowly to treatment.
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8/13. Penetrating keratoplasty in Mooren's ulcer.

    Two patients had bilateral, simultaneous Mooren's ulcers that progressed to almost total loss of the corneal stroma in all eyes. The conjunctival epithelium eventually healed over these thinned corneas and the eyes were free of pain and inflammation. Three of the four eyes had combined 7.5-mm penetrating corneal transplants and cataract extractions performed at least four months after disease activity had subsided. All transplants have remained transparent from one to three years postoperatively and there has been no evidence of recurrence of Mooren's ulcers.
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9/13. Peripheral corneal ulcers, conjunctival ulcers, and scleritis after cataract surgery.

    After undergoing uneventful cataract extractions, four patients developed an inflammatory reaction that included scleritis and peripheral corneal infiltrates and ulcers. Two of these patients also developed conjunctival ulcers. The inflammatory reaction in all four patients responded to topical corticosteroids.
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10/13. Marginal ulceration after intracapsular cataract extraction.

    In four cases of marginal corneal ulceration after uncomplicated intracapsular cataract extraction three of the ulcers appeared within three months after the surgery. In all patients the ulcers were located anteriorly to the site of limbal incision and were progressive. Conservative management was successful in three patients, including one after recurrence of the ulcer after surgery, and one patient resisted medical and surgical management.
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