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1/5. Asymptomatic vasculitis of the uterine cervix in presence of cervical intraepithelial neoplasia grade III.

    CASE REPORT: A 34-year-old woman was diagnosed to have a high-grade cervical intraepithelial neoplasia and was treated by large loop excision of the transformation zone. histology of the excised cone confirmed the diagnosis but also showed evidence of vasculitis of medium-sized vessels of the cervix. The woman was referred to a physician to rule out underlying systemic disease. Extensive laboratory and clinical screening was negative. DISCUSSION: The clinical significance and management of asymptomatic isolated vasculitis of the uterine cervix are discussed.
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2/5. Home Study Course: Fall 2005.

    OBJECTIVE: The Home Study Course is intended for the practicing colposcopist or practitioner who is seeking to develop or enhance his or her colposcopic skills. The goal of the course is to present colposcopic cases that are unusual or instructive in terms of appearance, presentation, or management, or that demonstrate new and important knowledge in the area of colposcopy or pathology. Participants may benefit from reading and studying the material or from testing their knowledge by answering the questions. ACCME accreditation: The American Society for colposcopy and Cervical pathology (ASCCP) is accredited by the accreditation Council for Continuing Medical education (ACCME) to provide continuing medical education for physicians. The ASCCP designates this continuing medical education activity for 1 hour Category I credit of the ASCCP's Program for Continuing Professional Development and the Physician's Recognition Award of the american medical association. Credit is available for those who choose to apply. The Home Study Course is planned and produced in accordance with the ACCME's Essential Areas and elements. disclosure: faculty must disclose any significant financial interest or relationship with proprietary entities that may have a direct relationship to the subject matter. For this course, the author had no such relationship to report.
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3/5. Home Study Course: summer 2006.

    OBJECTIVE: The Home Study Course is intended for the practicing colposcopist or practitioner who is seeking to develop or enhance his or her colposcopic skills. The goal of the course is to present colposcopic cases that are unusual or instructive in terms of appearance, presentation, or management, or that demonstrate new and important knowledge in the area of colposcopy or pathology. Participants may benefit from reading and studying the material or from testing their knowledge by answering the questions. ACCME accreditation: The American Society for colposcopy and Cervical pathology (ASCCP) is accredited by the accreditation Council for Continuing Medical education (ACCME) to provide continuing medical education for physicians. The American Society for colposcopy and Cervical pathology designates this educational activity for a maximum of 1 AMA PRA Categorys I Creditt. physicians should only claim credit commensurate with the extent of their participation in the activity. ASCCP also designates their educational activity for 1 Category 1 credit hour of the ASCCP's Program for Continuing Professional Development. Credit is available for those who choose to apply. The Home Study Course is planned and produced in accordance with the ACCME's Essential Areas and elements. DISCLOSURES: The clinical history and images in the Home Study Course may represent an actual case, but not always. To improve educational quality, some gross, cytological, or histological images may come from photographic libraries. Good teaching cases are often difficult to obtain, and we encourage our readers to submit cases with high-quality images to the Home Study Course editor or executive editor to consider for publication. Lastly, faculty must disclose any significant financial interest or relationship with proprietary entities that may have a direct relationship to the subject matter. For this course, the authors had no such relationship to report.
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4/5. Adverse effect of electrosurgical loop excision on assignment of FIGO stage in cervical cancer: report of two cases.

    Electrosurgical loop conization of the cervix is a new procedure that is being rapidly accepted for treatment of cervical intraepithelial neoplasia (CIN). Concerns include fragmentation of the specimen that is frequently mandated by the size of the transformation zone and difficulty in using the largest electrosurgical loops. Two cases are presented that demonstrate the inability to accurately assign depth of invasion in cervical cancer when the focus of invasion is transfected. As a result, the patient and physician were forced to decide on whether a radical hysterectomy and pelvic lymphadenectomy were needed based on incomplete information. It is recommended that electrosurgical loop conization be confined to patients where invasive carcinoma is not expected. The use of this new technique for patients with suspected invasive carcinoma needs further evaluation.
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5/5. Human papillomavirus-associated cervical intraepithelial neoplasia following lesbian sex.

    BACKGROUND: Less than 3% of lesbians develop cervical dysplasia, with increasing risk correlating with previous heterosexual activity. Because they are not currently sexually active with men, many lesbians do not perceive themselves to be at risk for developing dysplasia and do not obtain regular Papanicolaou smears. There are no standard recommendations for Papanicolaou smear intervals for lesbians. CASE: A 36-year-old, nonsmoking woman had a Papanicolaou smear history of a high-grade squamous intraepithelial lesion of the cervix, which was confirmed by biopsy and successfully treated by laser ablation. Human papillomavirus type 16 was identified in the cervical biopsy by polymerase chain reaction amplification and restriction fragment polymorphism analysis. The patient gave a clear history of having had sexual activity only with women. CONCLUSION: Regular Papanicolaou testing should be recommended to all lesbians, regardless of type of sexual activity. Papanicolaou testing intervals should be determined using standards similar to those used for heterosexual women: annually after onset of sexual activity or after age 18, and possibly less often after three normal smears at her physician's discretion. An extensive number of sexual partners, current smoking, and prior dysplasia may influence the physician to advise continued yearly Papanicolaou testing for lesbians, similar to advice given to heterosexual patients.
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