1/19. High grade MALT-lymphoma of the breast.A 65-year-old woman presented with a rapidly growing breast tumor, initially diagnosed as a carcinoma. histology showed a breast lymphoma of high grade MALT-type. A lymphoma should always be considered in the differential diagnosis of a breast tumor, because it needs a different work-up and treatment. The subgroup of NHL of Mucosa-Associated-Lymphoid-Tissue origin has different clinical behaviour, as illustrated in this report.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/19. Intracapsular carcinoma ex pleomorphic adenoma. Report of a case with unusual metastatic behaviour.Intracapsular carcinomas ex pleomorphic adenoma are exceedingly rare salivary glands tumours, known to have a benign clinical behaviour with metastatic unrecognised potential. We report a case of a 57-year-old female patient presenting with a typical example of intracapsular carcinoma ex pleomorphic adenoma of the parotid gland and evidence of ipsilateral cervical lymph node metastases two years before. The behaviour of this unique case illustrates the disputed malignancy of carcinomas arising within encapsulated pleomorphic adenomas.- - - - - - - - - - ranking = 6keywords = behaviour (Clic here for more details about this article) |
3/19. Salivary Gland Epithelial- Myoepithelial carcinoma: behaviour, diagnosis and treatment.Across the whole spectrum of the tumoral pathology in the maxillo-facial and cervical areas, we can find those tumours where the aetieology is in the salivary glands. The tumours in the salivary glands are subdivided in benign and malignant tumours whenever this theorical subdivision is possible. The Epithelial-Myoepithelial carcinoma represents about the 1% of the malignant neoplasms in the salivary glands and also affect other anatomical areas where there are glands: lung, kidney, uterus and so on. We start from a clinical case of a Epithelial-Myoepithelial of salivary minor gland carcinoma doing a bibliographic review of this unusual histological lineage. So we present a case of Epithelial-Myoepithelial carcinoma of a minor salivary gland in the right cheek. We'll review the clinical and histological features of this uncommon tumour. And we'll discuss about the best way for diagnosis, treatment and the differential diagnosis to similar clinical injuries.- - - - - - - - - - ranking = 4keywords = behaviour (Clic here for more details about this article) |
4/19. Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases.AIMS: To study 19 cases of primary thymic carcinoma in order to define the clinicopathological features and the precise histochemical profile of this rare and heterogeneous group of tumours of the anterior mediastinum. methods AND RESULTS: The study group consisted of 13 males and six females, with a mean age of 58.5 years (range 29-75 years). superior vena cava syndrome and chest pain were the main presenting symptoms. Three patients were asymptomatic. No patient had myasthenia gravis. Six different histological types were identified: neuroendocrine tumours (six patients), epidermoid carcinoma (five patients), sarcomatoid carcinoma (three patients), lymphoepithelioma-like carcinoma (two patients), mucoepidermoid carcinoma, clear cell carcinoma, and undifferentiated carcinoma (one patient each). The clear cell carcinoma was associated with a thymic cyst. No association with thymoma was observed. Surgical resection, performed in 10 cases, was complete in two. Sixteen patients received thoracic radiation, and 11 received systemic chemotherapy. Follow-up information was available in 16 cases; 12 patients presented with local or metastatic relapse, and 10 patients died of their tumour. The overall 5-year survival was 14.5%. CONCLUSION: Primary thymic carcinoma is a very heterogeneous group of tumours of the anterior mediastinum with an aggressive clinical behaviour, and a poor overall prognosis.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
5/19. OCT4 expression on a case of poorly differentiated (insular) carcinoma of the thyroid gland and minireview.Poorly differentiated (insular) carcinoma of the thyroid gland is rare and defined as follicular-cell neoplasms that show limited evidence of structural follicular cell differentiation and occupy both morphologically and behaviourally an intermediate position between differentiated (follicular and papillary carcinomas) and undifferentiated (anaplastic) carcinomas. The authors report a case of a 37-year-old Thai woman who presented with a prolonged left thyroid nodule. Final pathological diagnoses of her mass were poorly differentiated (insular) carcinoma with lymphovascular invasion and nodular goiter. The tumor cell arrangements were nest (insular) and trabecular patterns with some follicular formations. immunohistochemistry of the tumor cells revealed negative immunostaining for OCT4. Expression of OCT4 gene is involved in the regulation and maintenance of pluripotency of embryonic stem cells, germ cells, and in tumor cells. The authors believe that poorly differentiated (insular) carcinoma of the thyroid gland probably develops from the remnant of thyroid stem cells and is not associated with dedifferentiation (anaplasia or loss of cellular differentiation) from nodular goiter or cells of other thyroid carcinomas. Although there was negative immunostain for OCT4 in the presented case, the authors assumed that the tumor cells behave with an intermediate position between thyroid stem cells and prothyrocytes Also they do not behave with thyroblasts. Additionally, the tumor may be associated with new cellular dedifferentiation. However, there is only one case of immunohistochemistry of OCT4 in poorly differentiated (insular) carcinoma of the thyroid gland. Thus, prognosis of the presented still is mainly correlated with clinical and histological findings. Further research on expression of OCT4 gene on thyroid cancers and other malignant tumors relating to tumorigenic cancer cells (cancer stem cells) may be useful to prognostic evaluation and administration of a new chemotherapy and/or radiotherapy that is specific for tumor-initiating cells.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
6/19. Acinic cell carcinoma of minor salivary gland origin.The occurrence of acinic cell carcinoma in the minor salivary glands appears to be exceptional. A review of the English language literature revealed about 80 previously reported cases. In this paper, the clinical behaviour and pathological findings in three cases are reported. The tumours took their origin from the hard palate, soft palate and lower lip. The three cases presented with malignant clinical behaviour; all three recurred. In one case the local recurrence was multinodular with capsular infiltration. Two cases developed regional lymph node metastasis, and one metastasized to the lung and liver. In one the tumour infiltrated bony structures, and nerve in another. These cases tend to support the belief of some authors that acinic cell 'tumours' are clinically malignant and should be included in the carcinoma group.- - - - - - - - - - ranking = 2keywords = behaviour (Clic here for more details about this article) |
7/19. Primary sarcomatoid carcinoma of the adrenal gland. First case report.The first case of a sarcomatoid carcinoma of the adrenal gland is reported. The patient, a 68-year old woman, developed a recurrence two months after presentation and died of the disease 7 months later with multiple metastases. The differential diagnosis of this entity is discussed and its aggressive behaviour is emphasized.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
8/19. Metastases from carcinoma of the breast involving the central nervous system.A general discussion is made of the incidence, biological behaviour, diagnosis and management of metastatic disease involving the central nervous system secondary to malignant disease of the breast. Illustrative case histories selected from patients treated for carcinoma of the breast in the period 1978-88 are included.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
9/19. Secretory carcinoma of the breast in adults: emphasis on late recurrence and metastasis.Secretory (so-called juvenile) carcinoma of the breast, first described in children, occurs also in adult women, predominantly in the third decade. Less commonly it is seen in older age groups, up to the eighth decade. We report five patients with this tumour; one, a female aged 73, is the oldest age at which the tumour has been recorded, and one is the first report in an adult male in whom the disease recurred after 20 years, only the second recorded death attributable to this tumour type. Secretory carcinoma in adults is potentially more aggressive than in childhood. Nodal metastases are more frequent and sometimes more extensive. recurrence of tumour after surgery developed in four of our five patients at 3, 8, 15 and 20 years. Slow growth and delayed recurrence are characteristic of many of these tumours. death from systemic metastases is rare, but may ensue either rapidly or following a long latent period after treatment. Prolonged follow-up is needed to assess accurately the biological behaviour of this tumour.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
10/19. Extensive form of progressive multifocal leucoencephalopathy associated with laryngeal carcinoma.A case is reported of the rare association between progressive multifocal leucoencephalopathy and carcinoma. A 66-year-old man underwent a laryngectomy for carcinoma. Four years later he developed a local recurrence. Simultaneously there were behavioural disturbances and a left motor neglect followed by dense hemiplegia and coma. The patient died a further 5 months later. Anergy was demonstrated by skin tests. CT scan showed asymmetrical non-enhancing low-density areas in the hemispheric white matter, brain-stem and cerebellum and neuropathological examination confirmed extensive myelin loss with typical papovavirus inclusions in oligodendrocytes identified by electron microscopy.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
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