1391/1460. Oat cell carcinoma metastasis to the foot. Initial isolation from the foot of a highly malignant primary bronchogenic carcinoma, small cell carcinoma (oat cell carcinoma), was identified via excisional biopsy from the right foot of a 42-year old nonsmoking Caucasian female. This patient denied any pertinent prior medical history, other than persistent pain in her right foot for approximately 1 year before seeking care. Incidental trauma prompted her to seek care, which consisted of immobilization via a wooden shoe. When symptoms persisted, her primary care physician referred her to my office for further evaluation. ( info) |
1392/1460. Remission of cancer chemotherapy-induced emesis during antidepressant therapy with nefazodone. OBJECTIVE: To emphasize the importance of treating a major depressive episode in an elderly patient with small cell lung cancer (SCLC). METHOD: A case report is described to illustrate the importance of treating depression in an elderly patient with SCLC undergoing chemotherapy. RESULTS: During the course of antidepressant therapy with nefazodone, the patient also experienced a remission of cancer chemotherapy-induced emesis. CONCLUSIONS: This case report suggests that the remission of emesis could be related to the 5-hydroxytryptamine (5-HT) antagonistic property of nefazodone. ( info) |
1393/1460. Metastatic small-cell carcinoma of rectum responding dramatically to combination chemotherapy. Small-cell carcinoma of the rectum, is very rare with a dismal prognosis that follows a more aggressive course than the pure exocrine counterparts. As a result, survival is usually very poor. A male patient with metastatic disease is presented in this report. After receiving six cycles of combination chemotherapy regimen consisting of cyclophosphamide, adriamycin, and etoposide, he is in complete remission for >3 years. Although it is a single case, it shows that combination chemotherapy may achieve an excellent result even in a metastatic case of small-cell carcinoma of the rectum. ( info) |
1394/1460. Small cell sweat gland carcinoma in childhood. sweat gland carcinomas are rare skin tumors that typically occur in older patients. The spectrum of their clinical and pathologic features is broad, and many different types of sweat gland carcinomas have been described, ranging from fairly indolent to highly aggressive neoplasms. We present two cases of sweat gland carcinoma with a predominant small cell morphology. Both tumors occurred in children. One lesion developed in an 8-year-old girl as an asymptomatic papule on her left forearm, which ultimately was evaluated using biopsy because of rapid growth and change in color. The other lesion occurred on the hand of a 12-year-old boy. Both tumors were pandermal and extended into fat. They were composed of monotonous cuboidal cells with scant cytoplasm that formed tubules and grew in anastomosing cords and trabeculae. The tumor cells were immunoreactive for cytokeratins but not for cytokeratin 20. Ultrastructural analysis (available in one case only) showed that the tumor cells lacked neurosecretory granules. This variant of sweat gland carcinoma needs to be distinguished from other small cell neoplasms of the skin, especially Merkel cell carcinoma, its closest mimic. ( info) |
1395/1460. Small cell cancer of the cervix presenting as compression of the spinal cord and cauda equina. spinal cord or cauda equina compression by metastatic cancer usually occurs months or even years after the diagnosis of the primary tumor. We describe the unusual simultaneous presentation of small cell cancer of the cervix and metastatic tumor compressing the spinal cord and cauda equina. ( info) |
1396/1460. Oat cell carcinoma of the tongue from an unknown primary. Oat cell carcinoma is rarely diagnosed in the head and neck and can be primary or secondary. Primary tumors arise from amine precursor uptake and decarboxylation cells which are found throughout the head and neck. Secondary deposits metastasize most commonly from the lungs. We report a 64-year-old woman with a known pancreatic oat cell carcinoma who came to the ENT Department with dysphagia. On examination, a lesion was seen at the base of the tongue and was histologically an oat cell carcinoma. No treatment was administered and the patient died one month after discharge. This report highlights the difficulty in determining the primary site when a rare tumor metastasizes to the head and neck and no autopsy findings are obtained. To our knowledge, oat cell carcinoma of the tongue has not been previously reported. ( info) |
1397/1460. A case of rapidly progressing small cell lung cancer incidentally found during the course of renal failure. A 65-year-old man with rapidly progressing small cell lung cancer found in the course of renal failure is reported. The patient had a medical history of hypertension, diabetes mellitus, and cardiovascular disease. Hemodialysis was introduced following renal failure, but pneumonia resulted in a transient exacerbation and his complaint of general fatigue did not improve. Examination for the fatigue revealed no apparent abnormalities. Three months later, he died of small cell lung cancer. ( info) |
1398/1460. Anti-Hu-associated paraneoplastic sensory neuropathy with peripheral nerve demyelination and microvasculitis. A patient had a paraneoplastic autonomic, then sensory, then sensory-motor neuropathy with small cell lung carcinoma and a high titer Anti-Hu antibody to nuclei of neuronal cells. As an unusual finding there was electrophysiological and pathological evidence of demyelination and a peripheral nerve microvasculitis. The relationship of microvasculitis and peripheral nerve demyelination is discussed and their occurrence with paraneoplastic anti-Hu-associated sensory neuropathy is suggested not to be by chance. ( info) |
1399/1460. Spontaneous biloma as a complication of small cell lung cancer. Biloma is an extraductular collection of bile within a defined capsular space. Prior reports have documented an association between biloma and abdominal trauma, and between biloma and iatrogenic injury resulting from abdominal surgery, percutaneous catheter drainage, or transhepatic cholangiogram. To our knowledge, bilomas have not previously been associated with lung cancer. We report a case of spontaneous biloma that developed as a complication of small cell lung cancer. ( info) |
1400/1460. Vaginal small cell carcinoma mimicking a Bartholin's gland abscess: a case report. We report a case of a 32-year-old woman with a lesion in the vagina which clinically mimicked a Bartholin's gland abscess, but was demonstrated to be a small cell carcinoma by light microscopy. This tumor is very rare and to our knowledge there are 13 reported cases of primary vaginal small cell carcinoma in the English literature. The mean age of presentation of this neoplasm in the 13 reported cases is 61 with a median survival of 12 months. This case stresses the importance of considering this unusual diagnosis when confronted with a large or recurrent "Bartholin's gland lesion," and underlines the need for careful pathological examination of such specimens. ( info) |