1/1565. Multitechnical pathological diagnosis in chromophobe renal cell carcinoma.Two new cases of chromophobe renal cell carcinoma were diagnosed on the basis of their morphology and their karyotype complemented by flow cytometry. In one of these cases, however, all these investigations were not sufficient and additional histochemistry investigation had to be used to completely rule out other renal tumors such as oncocytoma, the prognosis of which is totally different.- - - - - - - - - - ranking = 1keywords = cell (Clic here for more details about this article) |
2/1565. Dendritic cell-based immunotherapy of renal cell carcinoma.dendritic cells potently stimulate antigen-specific immune responses and recent data indicate that they are also capable of eliciting antitumor immune responses. We are performing a pilot study which tests the safety and efficacy of antigen-loaded, cultured blood dendritic cells in patients with metastatic renal cell carcinoma. dendritic cells are simultaneously pulsed with lysate from autologous tumor cells and with the immunogenic protein keyhole limpet hemocyanin. During the pulse, the cells are activated with a combination of tumor necrosis factor-alpha and prostaglandin E2. patients receive 5-10 X 10(6) dendritic cells per intravenous infusion and up to six infusions at monthly intervals. The first results demonstrate that this treatment modality is very well tolerated and can be associated with strong immunological and clinical responses. The present article discusses the importance of dendritic cell maturation and the role of helper antigens in dendritic cell-based immunotherapy.- - - - - - - - - - ranking = 3.4keywords = cell (Clic here for more details about this article) |
3/1565. Unusual cause of intraoperative hypotension diagnosed with transoesophageal echocardiography in a patient with renal cell carcinoma.Transoesophageal echocardiography (TOE) is not commonly used in the management of non-cardiac cases. We report a case where the use of TOE played a major role in the intraoperative diagnosis and subsequent management of a patient exhibiting severe hypotension whilst undergoing a nephrectomy. The rare diagnosis of a secondary intraventricular tumour would not have been evident with more conventional monitoring techniques.- - - - - - - - - - ranking = 0.8keywords = cell (Clic here for more details about this article) |
4/1565. A reversible cause of hypercapnic respiratory failure: lower motor neuronopathy associated with renal cell carcinoma.We describe a unique case of a patient with a reversible paraneoplastic motor neuronopathy who presented with hypercapnic respiratory failure. The patient developed progressive respiratory and limb muscle weakness until treated with removal of a renal cell carcinoma, which was followed by a complete resolution of neuromuscular symptoms. The literature of paraneoplastic motor neuronopathies is reviewed, specifically in reference to respiratory failure.- - - - - - - - - - ranking = 1keywords = cell (Clic here for more details about this article) |
5/1565. Complete response of a large brain metastasis of renal cell cancer to interferon-alpha: case report.BACKGROUND: interferon-alpha (IFNalpha) is a drug widely used in the treatment of metastatic renal cell cancers, especially lung lesions. Successful treatment using IFNalpha for histologically proven brain metastasis has not been reported. CASE REPORT: A large pineal tumor was found in a 51-year-old man with renal cell cancer in the left kidney. The histological diagnosis of biopsied specimens was a brain metastasis from renal cell cancer. The patient was treated with intramuscular injections of IFNalpha. The brain metastasis gradually decreased in size and disappeared completely 6 months after the initial injection of IFNalpha. The IFNalpha therapy was continued for 9 months. Fifteen months later, no recurrence was evident on brain magnetic resonance imaging. CONCLUSION: This is an extremely rare case in which the long-term use of IFNalpha induced a complete response of a brain metastasis from renal cell cancer.- - - - - - - - - - ranking = 1.6keywords = cell (Clic here for more details about this article) |
6/1565. Surgical treatment of renal cell carcinoma associated with budd-chiari syndrome: report of four cases and review of the literature.AIMS: Renal cell carcinoma is sometimes associated with inferior vena caval tumour thrombus, but occlusion of hepatic veins by the tumour thrombus causing liver dysfunction, the so-called Budd Chiari syndrome, is relatively uncommon. There are only a few reports in the literature which discuss this condition. methods: Four cases admitted to our hospital over a 7-year period and eight cases reported in detail in the English and the Japanese literature were included in this study. They are classified into two groups: mild/silent, without liver failure, and severe, with liver failure. RESULTS: Five patients were classified as mild/silent and seven as severe. Clinical manifestations were mild in the former cases and acute in the latter. Surgery was performed in four of the former cases but only in one case of the latter cases. CONCLUSIONS: In mild cases, surgical treatment seems to avoid imminent hepatic failure effectively and should be performed as soon as possible. In such cases Budd Chiari syndrome in itself does not affect the prognosis. In severe cases, however, surgical treatment is very difficult and risky due to the existing hepatic failure.- - - - - - - - - - ranking = 1keywords = cell (Clic here for more details about this article) |
7/1565. Renal cell carcinoma in children with diffuse cystic hyperplasia of the kidneys.We report the clinical, pathologic, and genetic features of renal malignancy in two children with diffuse cystic hyperplasia. Both presented with massive bilateral nephromegaly. Neither had a family history or clinical findings suggestive of tuberous sclerosis or von hippel-lindau disease. The kidneys of both children were extensively replaced by tubulocystic hyperplasia with large eosinophilic epithelial cells. The masses of hyperplastic tissue were nodular, compressing remnants of uninvolved renal parenchyma. Tubulopapillary carcinoma was present in both children, one of whom had bilateral multicentric carcinoma. No loss of heterozygosity was detected in the tumors at the TSC1, TSC2, or VHL gene regions, and no alterations in the VHL gene were detected using single-strand conformation polymorphism analysis. These cases of bilateral renal enlargement with diffuse cystic hyperplasia appear to represent a new clinical syndrome that may warrant bilateral nephrectomy because of the risk of malignancy.- - - - - - - - - - ranking = 1keywords = cell (Clic here for more details about this article) |
8/1565. Renal cell carcinoma with a fatty component mimicking angiomyolipoma on CT.A very unusual CT appearance of renal cel carcinoma is presented, in which the fatty density mimicked a benign angiomyolipoma.- - - - - - - - - - ranking = 0.8keywords = cell (Clic here for more details about this article) |
9/1565. Bellini duct (collecting duct) carcinoma of the kidney.carcinoma of the collecting ducts, or Bellini carcinoma, is a rare renal tumour and, unlike most renal cell carcinomas, it derives from distal tubules. It displays highly aggressive behaviour and has a poor prognosis. In this study, the authors present three cases which they observed over the past three years.- - - - - - - - - - ranking = 0.2keywords = cell (Clic here for more details about this article) |
10/1565. Renal angiomyolipoma resembling gastrointestinal stromal tumor with skenoid fibers.We report an unusual case of renal angiomyolipoma occurring in 68-year-old man. The tumor lacked well-developed vascular and adipose components and was composed almost exclusively of smooth muscle cells. Numerous skenoid-like periodic acid-Schiff-positive globules were interspersed between the tumor cells; the lesion therefore closely resembled a low-grade stromal tumor of the gastrointestinal tract. The HMB45-positive/CD34-negative immunophenotype was essential for the diagnosis of angiomyolipoma. Neither gastrointestinal tumor nor any signs of tuberous sclerosis were found. This lesion should be included in the list of morphologic variations of angiomyolipoma, which may cause diagnostic difficulties.- - - - - - - - - - ranking = 0.4keywords = cell (Clic here for more details about this article) |
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