1/6. Metastatic endocervical adenocarcinoma presenting as a virilizing ovarian mass during pregnancy.BACKGROUND: We report a case of metastatic endocervical adenocarcinoma that presented as a virilizing ovarian mass in a young pregnant woman and simulated a primary ovarian endometrioid tumor. CASE: A 34-year-old woman underwent cesarean delivery and right salpingo-oophorectomy at 34 weeks' gestation for a 32-cm androgen-producing ovarian mass. The ovarian tumor, initially interpreted as a primary ovarian endometrioid carcinoma, was demonstrated to represent metastatic endocervical endometrioid adenocarcinoma based on detection of human papillomavirus 16 (HPV-16) deoxyribonucleic acid in the tumor by in situ hybridization. The hysterectomy specimen demonstrated an endocervical adenocarcinoma associated with adenocarcinoma in situ that also contained HPV-16. CONCLUSION: Human papillomavirus is considered an etiological agent in the development of endocervical adenocarcinomas, having been demonstrated in greater than 90% of tumors. In contrast, recent studies have concluded that HPV is unlikely to play an etiological role in ovarian neoplasia. The demonstration of HPV-16 in both the endocervical and ovarian carcinomas in this patient supports the interpretation that the ovarian tumor is a metastasis.- - - - - - - - - - ranking = 1keywords = pregnancy (Clic here for more details about this article) |
2/6. Serous adenocarcinoma of the inguinal region arising from endometriosis followed by a successful pregnancy.BACKGROUND: Inguinal serous carcinoma arising from endometriosis is an unusual cancer. It is uncertain how patients with these tumors should be managed, especially those patients who desire future fertility. CASE: We present a 34-year-old woman with a right groin mass with cyclical pain. Resection of this mass revealed complex atypical hyperplasia, well-differentiated endometrioid adenocarcinoma, and serous carcinoma within a focus of endometriosis. The patient desired to maintain her fertility and was treated conservatively. She is currently 3 years free of disease after diagnosis. She also had one successful pregnancy. CONCLUSION: This is a rare case of carcinoma arising from endometriosis. The long-term prognosis for this patient remains unclear and the patient will require long-term follow-up.- - - - - - - - - - ranking = 1.25keywords = pregnancy (Clic here for more details about this article) |
3/6. Endometrial adenocarcinoma associated with elevated serum concentrations of the free beta subunit of human chorionic gonadotropin.We report a case of a histologic grade II endometrial adenocarcinoma without trophoblastic differentiation in a 24-year-old woman with an elevated serum concentration of human chorionic gonadotropin (hCG) and with no evidence of pregnancy. serum and urine specimens were used to study the hCG immunoreactivity. Qualitative tests performed on serum and urine using 5 different assays produced conflicting results. The hCG concentration in serum and urine was quantified using assays designed to detect different molecular forms of the molecule; analysis revealed that serum hCG immunoreactivity was due entirely to the presence of the free beta subunit. Immunohistochemical analysis performed on tissue samples showed strong cytoplasmic staining for hCG. While hCG is a well-recognized tumor marker in gynecologic malignant neoplasms, immunoreactivity most often is due to the presence of both intact molecule and the free beta subunit. To our knowledge, this is the first report of an endometrial adenocarcinoma producing only the free beta subunit of hCG.- - - - - - - - - - ranking = 0.25keywords = pregnancy (Clic here for more details about this article) |
4/6. Progression of conservatively treated endometrial carcinoma after full term pregnancy: a case report.INTRODUCTION: We describe a case of conservatively treated endometrial endometrioid (EE) adenocarcinoma which showed an aggressive clinical outcome after pregnancy. CASE: A 30-year-old woman with a well differentiated EE adenocarcinoma decided to attempt a conservative approach and underwent progestin treatment with subsequent negative ultrasound and hysteroscopic controls. After 3 months, she conceived and at 36 weeks of gestation, a cesarean section was performed with multiple negative biopsies. Eight 8 months after delivery, an exploratory laparotomy documented disseminated poorly differentiated EE adenocarcinoma. Staging work up revealed diffuse metastatic disease. Despite chemotherapy, the patient experienced progression of disease with fatal acute respiratory syndrome due to massive neoplastic pulmonary lymphangitis. CONCLUSION: Conservative medical management of endometrial cancer in young women willing to preserve their reproductive potential, carries on potential risks. Careful selection of cases, informed consent, and strict follow up procedures are mandatory.- - - - - - - - - - ranking = 1.25keywords = pregnancy (Clic here for more details about this article) |
5/6. Successful pregnancy after hysteroscopic removal of grade I endometrial carcinoma in a young woman with Lynch syndrome.In a woman at the age of 30, carcinoma of the endometrium was diagnosed after hysteroscopic polypectomy. Her family history fulfilled Bethesda diagnostic criteria for Lynch syndrome or hereditary nonpolyposis colon cancer. Conservative treatment was chosen based on the tumor grade, her age, and her desire for pregnancy. Three months after high-dose progesterone treatment successful conception was achieved. In this report, we suggest that individual approach should be considered in young women with low-grade endometrial carcinoma, positive family history, and unfulfilled motherhood.- - - - - - - - - - ranking = 1.25keywords = pregnancy (Clic here for more details about this article) |
6/6. Ruptured malignant ovarian tumor mimicking ruptured ectopic pregnancy.Ovarian carcinoma is uncommon in premenopausal women and few cases appear during pregnancy. Acute symptoms, such as pain secondary to rupture or torsion, are unusual. The majority of women with epithelial ovarian carcinoma remain asymptomatic for long periods of time. When symptoms do occur they are often vague and nonspecific. Unsuspected ovarian carcinomas may be detected incidentally during routine obstetrical examinations. We present a case of ovarian carcinoma complicating an early pregnancy in a young woman with findings suggestive of ectopic pregnancy. The ultrasonographic findings also were initially thought to be consistent with ectopic pregnancy.- - - - - - - - - - ranking = 2keywords = pregnancy (Clic here for more details about this article) |