1/6. Basal cell carcinoma of the penis and scrotum with cutaneous metastases.A 75-year-old man presented with a multicentric basal cell carcinoma (BCC) of the penis and scrotum with skin metastases. The lesion was large, affecting the whole shaft, the scrotum, and the public and inguinal areas. The patient was operated on and the defect covered with a split thickness skin graft. At six months follow-up, the patient was well, with no evidence of recurrence. This site is extremely rare (we know of 24 cases described) but seems to metastasis widely. Surgery is the best treatment option in these cases, and must be aggressive, considering the particular biological behaviour of BCC of the genital region.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/6. dermatofibrosarcoma protuberans of the scalp.dermatofibrosarcoma protuberans is an uncommon tumour of the dermis and rarely occurs on the scalp; there are few known predisposing factors. A case is described of such a tumour that occurred at the site of radiotherapy for a basal cell carcinoma. Histological characteristics, behaviour and management of dermatofibrosarcoma protuberans are discussed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
3/6. Giant basal cell carcinoma of the thoracic wall: a case report and review of the literature.Giant basal cell carcinoma is a rare skin tumour with aggressive biological behaviour, and deep invasion and metastasis have been reported. The authors describe a giant basal cell carcinoma involving the anterior chest wall. The lesion infiltrated the mediastinum, occluding the left brachiocephalic vein. Vascular invasion caused venous occlusion affecting the left upper limb. Neither surgical treatment nor radiotherapy were practicable.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
4/6. Aggressive basal cell carcinoma of head and neck areas.Among skin cancers, basal cell carcinoma (BCC) is considered as a relatively indolent disease. Sometimes, these carcinomas have an unusual clinical behaviour, with extreme aggressiveness. Based on reports of eight cases of aggressive BCC of the head and neck areas, and after a review of the literature, we define three criteria of aggressiveness: (1) initial diameter greater than 1 cm, (2) more than two recurrences despite all tentative conclusions of adequate treatment, or (3) extension into any extracutaneous structure.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
5/6. Recurrent basal cell carcinoma of the back infiltrating the spine. Recurrent basal cell carcinoma.BACKGROUND. risk of basal cell carcinoma (BCC) recurrence appears to be related to tumor location, tumor size, treatment modality, radicalness of excision, and histologic type. Recurrences of BCC on the trunk and extremities are rare, with 97% of all recurrent lesions being located in the head and neck region. OBJECTIVE. This report concerns a man who had a BCC of the back removed with electrodesiccation and curettage in 1980 at the age of 36. In the following 10 years the patient experienced five recurrences and finally developed infiltration of the thoracic spine that precluded further attempts at radical excision of the neoplasm. methods AND RESULTS. The pathology of the BCC in our patient revealed a number of histologic features that have been associated with aggressive behaviour. These include an infiltrative growth pattern characterized by an irregular and acute tapered profile of the tumor cell groups and fibroblast-rich stroma, infiltrating invading tumour edges, poorly peripheral palisading, nuclear pleomorphism, and perineural invasion. CONCLUSION. Basal cell carcinomas that occur in sunlight-protected areas of the trunk of middle-aged individuals can occasionally exhibit aggressive and highly invasive features as well as a marked tendency for local uncontrollable recurrences. The prognosis for patients with this variety of BCC is poor, especially when progressive infiltration of deep tissues does not permit, as in our case, any possible further radical surgical procedure.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
6/6. Giant basal cell carcinomas: report of four cases and considerations.Four cases of giant basal cell carcinoma (BCC) are reported and the problems of giant BCCs are briefly discussed. In particular, we consider the relationship between the size of the tumor and its clinical behaviour. The importance of the site location in tumor development the histologic subtypes involved, the associated findings, and problems of treatment are also discussed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |