1/9. Myofibroblastoma of the breast with hemangiopericytoma-like pattern and pleomorphic lipoma-like areas. Report of a case with diagnostic and histogenetic considerations.Myofibroblastoma (MFB) of the breast is an uncommon benign spindle cell tumor which may exhibit a wide spectrum of histological features. We report an unusual case of MFB of the male breast, showing cellular areas with a hemangiopericytoma-like pattern similar to that observed in solitary fibrous tumor (SFT) and extensive fibromyxoid areas containing numerous atypical stromal cells. The association of these atypical cells with mature adipocytes and microcystic and/or myxoid degenerative changes resembled pleomorphic lipoma-like and myxoid liposarcoma-like features, respectively. To our knowledge, these peculiar morphological findings have not been previously reported in MFB of the breast. They should be recognized to avoid confusion with other mesenchymal tumors, especially with hemangiopericytoma, pleomorphic lipoma (PL), spindle-cell lipoma (SCL) and myxoid liposarcoma. A case of MFB of the breast showing morphological features also commonly seen in SFT and PL/SCL is further morphological evidence in support of the speculation that the mesenchymal tumors of the breast, also known under the terms benign spindle cell tumors, fibromas, SFTs, SCLs and MFBs, are histogenetically related lesions.- - - - - - - - - - ranking = 1keywords = spindle cell, spindle (Clic here for more details about this article) |
2/9. Myofibroblastoma of the breast with diverse histological features.We report two cases of myofibroblastoma with unusual pathological features, in a 66-year-old woman and a 49-year-old man. Both tumours were unilateral, grossly nodular and well circumscribed, but not encapsulated. The lesions were made up of bipolar spindle cells arranged in fascicular clusters separated by bands of hialinized collagen; one included several islands of mature cartilage next to fat cells. The other contained atypical mononucleated and multinucleated giant cells. No mitotic figures were observed. Immunohistochemically, both tumours showed strong and diffuse cytoplasmic staining for vimentin and CD 34 and focal positivity for alpha-smooth muscle actin, and both were negative for cytokeratins, CD 68, Ham 5, 6, Mac 387, and S-100 protein. desmin was positive in one case. Ultrastructural study revealed populations composed of fibroblastic cells without signs of myofibroblastic differentiation in one case; the second featured abundant undifferentiated mesenchymal cells with myofibroblastic differentiation. Both patients remain disease-free 38 and 36 months after lumpectomy.- - - - - - - - - - ranking = 0.44560284305691keywords = spindle cell, spindle (Clic here for more details about this article) |
3/9. Myofibroblastoma of breast: evidence favoring smooth-muscle rather than myofibroblastic differentiation.A histopathological study of two cases of the tumor known in the literature as myofibroblastoma of the breast is presented. The tumors occurred in Caucasian males aged 57 and 62 years. Histologically, these were moderately cellular, lobulated spindle-cell lesions, each with a reasonably well-delineated edge with surrounding fatty connective tissue. No breast ducts or lobules were present. Tumor cell nuclei were bland, with small nucleoli and some nuclear grooving. Nuclear atypia and mitoses were absent. Immunostaining revealed positivity for a-smooth-muscle actin, desmin, and CD34. Tumor cells contained rough endoplasmic reticulum, bundles of myofilaments with focal densities, intermediate filaments, attachment plaques alternating with plasmalemmal caveolae, and focal lamina. Ultrastructural findings pointed to true smooth-muscle differentiation, and the cell-surface in particular lacked surface features of myofibroblasts (fibronectin fibrils [microtendons] and fibronexus junctions). These and published data suggest that at least some of the lesions referred to in the literature as myofibroblastoma may not be myofibroblastic and may be better designated as myogenic stromal tumors or as variants of leiomyoma.- - - - - - - - - - ranking = 0.10879431388617keywords = spindle (Clic here for more details about this article) |
4/9. Myofibroblastoma of the breast: genetic link with spindle cell lipoma.Mammary myofibroblastoma is a rare tumour, mainly occurring in male patients. This paper describes two cases of mammary myofibroblastoma, with typical histological features, including the presence of fat cells and mast cells. Immunohistochemically, the spindle cells stained positively for desmin and CD34. Cytogenetically, both tumours showed partial monosomy 13q and in case 1, there was, in addition, partial monosomy 16q. Rearrangements affecting 13q and 16q occur typically in spindle cell lipomas. In addition to histological similarities, the hitherto unreported chromosomal changes in mammary myofibroblastoma, which are similar to the chromosomal aberrations in spindle cell lipoma, strongly suggest a link between these two tumours and are not in favour of myofibroblastoma being a primary solitary fibrous tumour of the breast.- - - - - - - - - - ranking = 3.1192199013984keywords = spindle cell, spindle (Clic here for more details about this article) |
5/9. Myofibroblastoma of the male breast: a diagnostic problem on fine-needle aspiration cytology.Myofibroblastoma is an uncommon neoplasm of the male breast. Herein, we describe the cytologic features seen in the fine-needle aspirate of a 45-year-old man. The smears were cellular with intimate association of tumor cells with extracellular matrix material. The cells were spindle to polygonal and were without significant atypia. Numerous mast cells were observed. Nuclear grooving was present only occasionally, although this was conspicuous histologically. The presence of hyaline bands in between tumor cells, another interesting feature, was appreciated retrospectively. This neoplasm was initially misinterpreted as a malignant soft tissue tumor. awareness of the cytologic features coupled with mammography should prevent a misdiagnosis of this tumor.- - - - - - - - - - ranking = 0.10879431388617keywords = spindle (Clic here for more details about this article) |
6/9. Cytologic diagnosis of neurilemomas of male breast by fine needle aspiration.Among 217 cases of male breast lesions subjected to fine needle aspiration cytology(FNAC) over a period of nine years, three cases were found to be having neurilemomas, The review of literature reveals the first case of neurilemoma of male breast diagnosed by FNAC was reported in 1992. Very scanty literature is available on this rare tumour of male breast. The aspirates yielded cellular smears composed of clusters of spindle shaped cells and Verocay bodies. Histopathological examination of the excised masses confirmed the cytological diagnosis.- - - - - - - - - - ranking = 0.10879431388617keywords = spindle (Clic here for more details about this article) |
7/9. Myofibroblastoma of the breast.Myofibroblastoma of the breast is an uncommon stromal tumor most often found in older men. It usually presents as a solitary well-circumscribed breast lesion consisting of slender bipolar spindle cells and broad bands of hyalinised collagen. This is the first documented case of myofibroblastoma of the breast in australia. Found in a 71-year-old man, this case demonstrates many of the typical features of this entity. A history of previous trauma to the chest wall was present in this case, a finding only rarely associated with this lesion.- - - - - - - - - - ranking = 0.44560284305691keywords = spindle cell, spindle (Clic here for more details about this article) |
8/9. Myofibroblastoma associated with bilateral gynecomastia: a case report and literature review.Myofibroblastoma of the breast is a recently recognized benign mesenchymal mammary tumor that typically occurs as a unilateral, solitary lesion. Myofibroblastomas are well-circumscribed, unencapsulated tumors characterized by spindle cells in fascicles which exhibit varying degrees of myogenic and fibroblastic differentiation. Our case reports a mammary myofibroblastoma occurring in an 82-year-old male with gynecomastia and reviews the reported incidence of this benign spindle cell tumor in the world literature.- - - - - - - - - - ranking = 0.89120568611383keywords = spindle cell, spindle (Clic here for more details about this article) |
9/9. Fine needle aspiration cytology presentation of a cellular variant of breast myofibroblastoma. Report of a case with immunohistochemical studies.BACKGROUND: Myofibroblastoma is a benign stromal tumor of the breast that occurs mainly in males. There are few reports on the cytologic aspects of breast myofibroblastoma, all of them corresponding to the classic type. Recently, some variants of myofibroblastoma were histologically described as: collagenized, epithelioid, cellular and infiltrant. Presently, the variant forms of myofibroblastoma have not been well characterized pathologically or clinically. CASE: A case of a cellular variant of myofibroblastoma was diagnosed by fine needle aspiration in a 68-year-old male. The aspirates consisted of highly cellular, cohesive groups of randomly arranged, plump oval and spindle cells. The nuclei had fine, uniformly distributed chromatin with inconspicuous nucleoli, and mild pleomorphism was observed. The cytoplasm was scant, with ill-defined borders. We did not observe epithelial components, inflammatory cells or collagenous stroma. Histologic examination showed a dense proliferation of interlacing, spindle-shaped neoplastic cells, with some nuclear atypia. Conspicuous collagen bands were present only focally in the tumor. The margins of the specimen were free, but the tumor had infiltrative borders microscopically. The spindle cells showed immunoreactivity for vimentin, desmin, muscle-specific action and CD 34. CONCLUSION: Our case of a cellular variant of myofibroblastoma of the breast with expression of CD 34 adds more one benign spindle cell lesion of the breast that should be considered among the diagnostic possibilities for aspirates from this group of lesions.- - - - - - - - - - ranking = 1.4456028430569keywords = spindle cell, spindle (Clic here for more details about this article) |