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11/14. Weight reduction. Renal mineral and hormonal excretion during semistarvation in obese patients.

    Three patients with exogenous obesity were studied while fed a 400-kcal constant metabolic diet, provided as a single daily meal served at consecutive ten-day periods, starting with either the "breakfast" protocol at 8 AM or the "dinner" protocol at 5 PM. Both patients 1 and 2 had notably greater weight loss with the breakfast protocol than with the dinner. However, in patient 3 this difference was not demonstrated. urine samples, collected at four-hour intervals throughout the studies and analyzed for sodium, potassium, calcium, phosphorus, 17-hydroxycorticosteroids, and aldosterone secretions, showed differences in excretion of minerals and hormones with the timing of meals. The data tentatively show an achievement of greater weight loss when the isocaloric diet is given at 8 AM.
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12/14. Maturity-onset diabetes of the young: an illustrative case for control of diabetes and hormonal normalization with dietary management.

    The efficacy of diet therapy used for one patient with the newly classified maturity-onset diabetes of the young (MODY) is reported. Using the conventional American Diabetes association's food exchange system with appropriate caloric restriction, the patient's weight was reduced from 25% to 6% above ideal body weight in the 14-wk study. Results of three meal tolerance tests compared with a group of lean, normal subjects revealed a steady improvement from baseline and postprandial hyperglycemia, with concomitant normalization of the counterregulatory hormones as well as hemoglobin A1, free fatty acids, and subsequent euglycemia. This case demonstrates the effectiveness of dietary manipulation as the major therapy in MODY with obesity.
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13/14. Behavioral treatment of obesity in patients with prader-willi syndrome.

    Self-monitoring combined with contingency contracting resulted in weight loss, modification of dysfunctional eating habits, and increased or sustained exercise rates for two obese, mentally retarded adolescent females with prader-willi syndrome. Contingency contracting between clients and their parents/caregivers was used to specify consequences for daily self-monitoring, reduced caloric intake, weight loss, and exercise. punishment for food stealing was also employed. Results suggest that contingency contracting is an effective technique for producing long-term weight loss in obese mentally retarded adolescents. Further, these techniques offer an alternative to the clinician considering solely dietary restriction or surgical intervention.
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14/14. Modifying problematic mealtime interactions of children with cystic fibrosis and their parents via behavioral parent training.

    Implemented behavioral parent training targeting maladaptive mealtime behavior with two children with cystic fibrosis (CF) and their parents. Treatment was implemented in multiple baseline fashion across the two families. Primary dependent measure was coding of parent and child behaviors from videotaped dinners. Data were also collected on the children's daily calorie intake and weight. During treatment and at the posttreatment follow-ups, parents' attention to disruptive behavior decreased, attention to appropriate eating increased, and parental control at meals increased. The children showed an increase in appropriate behavior and a decrease in disruptive behavior; caloric intake and weight also improved. Results are discussed in terms of the applicability of behavioral intervention with feeding problems in children with CF.
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