1/7. Immune haemolysis after renal transplantation secondary to ABO minor-mismatch between donor and recipient.Immune haemolysis following renal transplantation has been reported and known causes include infection, medication and metabolic disturbances (1,2). Autoimmune haemolysis after renal transplantation secondary to ABO minor mismatch is an uncommon but important cause that should be considered in the differential diagnosis of post-transplantation haemolysis. A case of haemolytic anaemia caused by graft versus host antibody formation is presented. We suggest that direct Coomb's test should be done as a routine in all cases of ABO mismatch renal transplantation and red cells compatible with both donor and recipient or group "O" packed cells should be transfused if transfusion is indicated.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
2/7. Severe haemolysis and renal failure in a patient with paroxysmal nocturnal haemoglobinuria.Transfusion of about 60 ml of ABO incompatible plasma in 4 units of pooled platelets precipitated severe haemolysis, unmasking the emergence of paroxysmal nocturnal haemoglobinuria (PNH), in a patient with aplastic anaemia. in vitro tests showed that her red cells were lysed by both ABO compatible and incompatible plasma from normal donors. The behaviour of this case and the in vitro results suggest that it might be hazardous to relax the longstanding recommendation on transfusing patients with PNH by restricting the washing of blood components to those containing ABO incompatible plasma.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
3/7. ABO incompatibility due to immunoglobulin g anti-B antibodies presenting with severe fetal anaemia.ABO incompatibility is a common haematological problem affecting the newborn. The haemolysis is widely accepted to follow a relatively benign course rarely causing the escalating levels of hyperbilirubinaemia and significant anaemia associated with Rh haemolytic disease of the newborn. case reports of fetal hydrops secondary to ABO incompatibility are particularly rare. We describe two cases, first that of a twin pregnancy with both fetuses developing severe anaemia at 20 weeks gestation, and then a second case of a preterm baby demonstrating aggressive haemolysis and anaemia within hours of delivery. Both mothers were of black Africian origin and both were identified to have elevated titres of IgG anti-B antibodies.- - - - - - - - - - ranking = 7keywords = anaemia (Clic here for more details about this article) |
4/7. Late onset neonatal anaemia due to maternal anti-Ge: possible association with destruction of eythroid progenitors.There have been no reports of severe haemolytic disease of the newborn (HDN) due to Gerbich (Ge) antibodies. Two babies with HDN due to anti-Ge3, both born to the same mother, are described. The anti-Ge appeared in the first pregnancy and was not detectable in the first trimester, the babies' reticulocyte and bilirubin values were not greatly elevated (similar to HDN due to Kell antibodies), and the anaemia in both cases was either not apparent or not severe until 2 to 4 weeks after birth. Ge antigens are found on glycophorins (GPs) C and D; GPC, like Kell, has been shown to be expressed early on erythroid progenitor cells. The maternal anti-Ge3 was shown to promote phagocytosis of Ge early erythroid progenitors by monocytes (similar to what has been reported with anti-K and K progenitor cells). Thus, anti-Ge3 may cause immune destruction of erythroid progenitors and possibly suppression of erythropoiesis (which would explain the reticulocyte and bilirubin values seen in both cases). Anti-Ge3 appears to be capable of causing severe HDN. We suggest that babies born to mothers with anti-Ge should have their haemoglobin concentrations monitored for signs of anaemia for several weeks after birth. Functional assays may prove useful.- - - - - - - - - - ranking = 6keywords = anaemia (Clic here for more details about this article) |
5/7. Allogeneic bone marrow transplantation across the ABO barrier.Allogeneic bone marrow transplantation in severe aplastic anaemia has been shown to be a worth-while procedure. A case in which a group O patient received a successful marrow transplant from a group B donor is reported. Major ABO incompatibility is not a contraindication to bone marrow transplantation.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
6/7. Mismatched blood transfusion. A case report.blood transfusion reactions due to mismatching are fortunately very rare. A case of a patient being given incompatible blood to correct postoperative anaemia is reported and the management discussed.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
7/7. Sinusoidal fetal heart rate pattern with severe fetal anaemia. Case report.A sinusoidal fetal heart rate pattern, associated with Kell incompatibility, severe fetal anaemia, maternal hypertension and intrauterine fetal growth retardation, is described. The mechanism and management are discussed.- - - - - - - - - - ranking = 5keywords = anaemia (Clic here for more details about this article) |