1/11. dapsone-induced haemolytic anaemia and agranulocytosis in a patient with normal glucose-6-phosphate-dehydrogenase activity.A case of dapsone-induced severe haemolytic anaemia and agranulocytosis is described. A possible common pathogenic mechanism for the simultaneous occurrence of these side effects of dapsone therapy in a patient with normal glucose-6-phosphate-dehydrogenase activity is proposed.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
2/11. agranulocytosis and anaemia induced by sulfametopyrazine in a sulfametopyrazine-trimethoprim combination.We report a case of prolonged fever, agranulocytosis, and anaemia associated with the long acting sulphametopyrazine-trimethoprim combination (Kelfiprim). A woman of 23 years took an overdose of 13 tablets over five days for presumed cystitis. One day after the last dose the patient developed fever and a generalised rash. The fever persisted and her previously normal leukocyte count decreased to 1.8 x 10(9)/1. After treatment with paracetamol the fever settled briefly, and then recurred for another 16 days. A later peripheral blood leukocyte count of 0.77 x 10(9)/1, haemoglobin of 10.8 g/dl, and a hypocellular bone marrow with depressed granulopoiesis and haemopoiesis suggested marrow suppression induced by sulfametopyrazine. Since the IgM antibody against the Epstein-Barr virus capsid antigen was detected, the adverse drug reaction might have been aggravated by this virus. The case highlights the risk of severe haematological adverse reactions associated with sulphonamide treatment, and argues for the use of trimethoprim alone for uncomplicated cystitis.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
3/11. Primary cutaneous bacillus cereus infection in neutropenic children.A review of culture reports for a five-year period at St Jude Children's research Hospital yielded 10 cases of primary cutaneous bacillus cereus infection in neutropenic patients treated for cancer or aplastic anaemia. Vesicles or pustules were seen only on the limbs. The infections, all of which arose in the spring or summer, responded to antibiotics. In neutropenic patients B cereus should thus be regarded as a possible cause of isolated vesicles.- - - - - - - - - - ranking = 0.2keywords = anaemia (Clic here for more details about this article) |
4/11. CFU-GM inhibitors in neutropenia.Peripheral blood lymphocytes from 20 patients with neutropenia not consistent with aplastic anaemia were tested for their ability to inhibit the proliferation of normal granulopoietic precursor cells (CFU-GM) in agar culture. Two patients, both with features of an autoimmune disorder, had lymphocytes which were more inhibitory than normal lymphocytes to both normal and their own CFU-GM. Two other patients had lymphocytes which were more inhibitory than normal lymphocytes to either their own CFU-GM or normal CFU-GM but not both. Eight patients had lymphocytes which were significantly less inhibitory than normal lymphocytes to either normal or their own CFU-GM, but only one showed this feature against both normal and their own CFU-GM. One patient had a highly potent plasma inhibitor of CFU-GM--this patient had received multiple transfusions and had a leucocyte antibody of a broad specificity. No clinical or haematological features were common to any of these groups of patients which reflects the heterogeneity of patients studied and stresses the importance of controls.- - - - - - - - - - ranking = 0.2keywords = anaemia (Clic here for more details about this article) |
5/11. Response of neutropenia and anaemia to immunosuppressive therapy: report and bone marrow culture studies.Soft agar culture of bone marrow cells was used to investigate abnormalities of granulopoiesis in a patient with acquired anaemia and neutropenia which responded to immunosuppressive therapy. Results showed that the patient's peripheral blood leucocytes inhibited granulopoiesis in vitro. Variation in the response of different target marrows suggested that inhibition was not due to direct action on granulocyte-monocyte committed stem cells but was directed against or mediated through the cells in target marrow samples which produce granulopoietic stimulators. cell separation showed that the inhibitory activity was associated with the patient's mononuclear cells rather than neutrophils. A tentative explanation of the mechanism of production of the anaemia is also offered.- - - - - - - - - - ranking = 1.2keywords = anaemia (Clic here for more details about this article) |
6/11. Cephalosporin-induced immune neutropenia.neutropenia is an occasional complication of treatment with cephalosporin antibiotics. This report describes two patients who had neutropenia while receiving high doses of cephalosporins. The neutrophil counts returned to normal after stopping the drug, and cephalosporin-dependent neutrophil antibodies were demonstrated in both cases, using the granulocyte immunofluorescence test. In one patient, the immune neutropenia appeared to be due to a drug adsorption mechanism similar to penicillin-induced haemolytic anaemia, while an immune complex mechanism may have been involved in the second patient.- - - - - - - - - - ranking = 0.2keywords = anaemia (Clic here for more details about this article) |
7/11. Anaemia and agranulocytosis associated with ticlopidine therapy.Although ticlopidine has proven anti-aggregant properties, complications due to side-effects, particularly to the haemopoietic system, have been noted since it was recently launched on the market. We here report a case of bicytopenia (anaemia and granulocytopenia) associated with ticlopidine treatment.- - - - - - - - - - ranking = 0.2keywords = anaemia (Clic here for more details about this article) |
8/11. blood dyscrasias and mianserin.Four cases are described in which the drug mianserin was implicated in the development of leucopenia. In one case this was accompanied by fatal aplastic anaemia. In a second, generalized bone marrow depression occurred, although leucopenia was the only clinically significant manifestation. mianserin may depress bone marrow function and haematological surveillance is appropriate for patients taking this drug.- - - - - - - - - - ranking = 0.2keywords = anaemia (Clic here for more details about this article) |
9/11. Reversible severe anaemia and granulocytopenia caused by procainamide. A case report.A 64-year-old male developed severe anaemia during procainamide therapy. At the same time granulocytopenia was found. Discontinuation of procainamide led to complete recovery. Severe anaemia due to the use of procainamide is not well known. The available data indicate a maturation block of the erythropoiesis as the possible cause of the anaemia, perhaps in combination with an autoimmune haemolysis.- - - - - - - - - - ranking = 1.4keywords = anaemia (Clic here for more details about this article) |
10/11. serum inhibitors of myelopoiesis.A modification of the microcytotoxicity assay of Terasaki & McClelland was used to screen for serum inhibitors of myeloid progenitor cells (CFU-C). Sera from 104 patients with neutropenia or bone marrow failure and from 104 controls, including 30 normal subjects and 74 patients with various disorders or multiple transfusions, were studied. Inhibitors of CFU-C were found in 19 of the 104 patients with neutropenia or marrow failure: three with acquited neutropenia and 16 with aplastic anaemia. In 17 of the 19 patients the inhibitor was either complement dependent or chavincingly associated with clinical remission of disease in one patient. In another patient, the inhibitor was an IgG antibody directed against non-HL1 antigens present on CFU-C of all 50 normal target marrows tested; however, it was not clearly autoreactive. Inhibitors were also found in one of nine patients with lupus erythematosus, one with breast carcinoma, one patient with renal transplant rejection, and six of 46 multiply transfused patients without marrow failure. Our findings indicate that most serum inhibitors are associated with multiple transfusion: convincing evidence of pathogenetically important autoreactive antibody was present in only one of 19 patients with inhibitors.- - - - - - - - - - ranking = 0.2keywords = anaemia (Clic here for more details about this article) |
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