1/4. Adrenocortical oncocytoma.The histopathology and ultrastructural features of an adrenocortical oncocytoma are reported. The tumour was discovered incidentally during investigation for hypertension in a 72 year old female. Oncocytic tumours of the adrenal cortex are rare, with only 20 examples described in English language reports. Most have been non-functioning and benign, like the present example. Molecular studies may help assess the significance of oncocytic change in the pathogenesis and behaviour of oncocytic neoplasms.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
2/4. Malignant oncocytoma of a minor salivary gland: an unusual presentation at the base of the tongue.In contrast to malignant oncocytomas of the parotid gland, malignant oncocytomas arising from minor extraparotid glandular tissue are rare. The latter may display a locally aggressive behaviour as well as a variable tendency to develop secondary cervical lymph nodes. We report a new case of malignant oncocytoma in a 43-year-old man presenting with greatly enlarged cervical lymph nodes accompanied by a poorly defined swelling at the base of the tongue microscopically identified as a malignant oncocytoma. The diagnosis was strongly supported by the ultrastructural features of the cells almost completely filled with mitochondria. The cervical mass was excised, and the patient has suffered no recurrence for nearly 2 years after surgical treatment.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
3/4. Hurthle cell carcinoma: a clinicopathological study of thirteen cases.BACKGROUND: Hurthle cell carcinoma (HCC) of the thyroid is a variant of follicular cancer which has been considered by many as a more aggressive disease than the usual well-differentiated carcinoma of the thyroid. AIM: To investigate the clinico-pathologic characteristics, treatment and outcome of Hurthle cell carcinoma. MATERIAL AND methods: During a 7-year period, 13 patients (seven male, six female; mean age at diagnosis 48.4 /-13.2 years) with HCC were treated and monitored at the Ankara University. The measured diameter of the tumours varied from 1 to 6 cm in diameter with pathological examination. Three of the HCC had extra thyroid invasion, five had intrathyroid invasion, and five were encapsulated. One of the patients had a history of low-dose external radiation to the head and neck in childhood. Treatment consisted of a total thyroidectomy in 12 patients, and a near total thyroidectomy in one patient. At surgery, lymph node metastases were present in three patients and lymph node dissection were performed in these patients. Distant metastases were detected in only one patient (lung metastasis). RESULTS: All patients had radioiodine ablation therapy for residual thyroid tissue. Twelve of the 13 patients were ablated with a single dose of 131 I (3.7-5.5 GBq). A second dose of radioiodine therapy was required in only one patient who had lung metastases and this patient is still being followed up. After a median follow-up period of 85 months, there was no recorded mortality due to the disease and 12/13 of the patients were categorized as disease free (criteria for ablation were a negative I whole-body scan and very low serum thyroglobulin levels). CONCLUSION: We did not find higher incidences of local recurrences, distant metastases or mortality rates compared to well differentiated thyroid carcinomas. HCC of the thyroid and well differentiated thyroid carcinomas have similar biological behaviour. Their treatment should be similar, including total or near-total thyroidectomy plus modified cervical node dissection when there is lymph node involvement. Radioactive iodine therapy and suppressive laevothyroxin therapy should follow.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |
4/4. Oncocytoma of the nasal cavity: report of a case and review of the literature.The authors present a case of oncocytoma of the nasal cavity in a 60-year-old woman. The tumour shows the same histological and ultrastructural characteristics of oncocytomas arising in minor salivary glands of other sites and major salivary glands. The authors stress that the biological behaviour of oncocytomas of the nasal cavity seems related to their local growth rather than to the cytological characteristics of the tumour. The extreme rarity of this tumour in the nasal cavity is particularly emphasized. The few cases reported previously in literature are briefly reviewed.- - - - - - - - - - ranking = 1keywords = behaviour (Clic here for more details about this article) |